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Free Content Leptomeningeal Neoplasm and Mimics: A Pictorial Review

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Leptomeningeal enhancement is seen in a variety of primary and metastatic neoplasms. Other conditions, including inflammatory disease, infection, and infarction, can also present with leptomeningeal enhancement. MR imaging has a critical role in the identification of leptomeningeal disease; however, the differential diagnosis of leptomeningeal enhancement is broad, and clues to the diagnosis involve evaluation of the pattern and distribution of enhancement, associated imaging findings, the patient's clinical presentation, and, ultimately, CSF analysis. The purpose of this pictorial review was to familiarize the radiologist with imaging manifestations of leptomeningeal disease across a broad range of neoplastic and non-neoplastic processes.

Learning Objective: To review the imaging manifestations of leptomeningeal disease in a broad range of neoplastic and non-neoplastic mimicking entities.
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Keywords: CSF = cerebrospinal fluid; DWI = diffusion-weighted image; MPRAGE = magnetization-prepared rapid acquisition of gradient echo; MS = multiple sclerosis; SMART = stroke-like migraine attacks after radiation therapy; TB = tuberculous

Document Type: Research Article

Publication date: July 1, 2017

More about this publication?
  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities.

    Visit to view all available CME courses.

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