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Free Content Diffusion Tensor Tractography for Understanding Complex Brain Fiber Connectivity in Holoprosencephaly: A Unique Case Presentation

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Holoprosencephaly is the most common developmental disorder of the prosencephalon. We present a case of alobar holoprosencephaly with cortical migration anomalies, a large midline mass, a monooptic nerve, and no dorsal cyst. Diffusion tensor tractography showed markedly abnormal supratentorial and posterior fossa white matter fibers, along with an enlarged hippocampal commissure across the dorsal midline cerebrum and a monooptic nerve projecting toward the cerebellum. Fiber tracking revealed information about white matter composition and organization not evident with conventional MR imaging.
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Keywords: DTI = diffusion tensor imaging; DTT = diffusion tensor tractography; HPE = holoprosencephaly; MR = magnetic resonance; SHH = sonic hedgehog

Document Type: Research Article

Publication date: September 1, 2015

More about this publication?
  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities.

    Visit to view all available CME courses.

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