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Free Content Neuroimaging Findings in Toxic Brain Injuries

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The neurotoxic effects of various drugs and metabolites are often overlooked in the larger picture of complex medical problems. However, with the advent of novel MR imaging techniques, these neurologic effects are being increasingly recognized. These agents include exogenous and endogenous metabolites, and their manifestations may be subtle to recognize. The reversibility of their neurotoxic effects depends on prompt radiologic recognition of the neuroimaging findings to alert the ordering physicians and to initiate appropriate therapy. In this article, the neurotoxic potential of various metabolites is presented and their MR imaging findings are summarized.
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Keywords: ADC = apparent diffusion coefficient; CNS = central nervous system; DKA = diabetic ketoacidosis; DWI = diffusion-weighted imaging; FLAIR = fluid-attenuated inversion recovery; GRE = gradient-recalled echo; MBD = Marchiafava-Bignami disease; MELAS = mitochondrial encephalopathy, lactic acidosis, and strokelike episodes; MTX = methotrexate; ODMS = osmotic demyelination syndrome; PRES = posterior reversible encephalopathy syndrome; TIWI = T1-weighted imaging; WE = Wernicke encephalopathy

Document Type: Research Article

Publication date: June 1, 2012

More about this publication?
  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities.

    Visit to view all available CME courses.

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