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Free Content Intraocular/Intracranial Pressure Mismatch Hypothesis for Visual Impairment Syndrome in Space

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Zhang L-F, Hargens AR. Intraocular/intracranial pressure mismatch hypothesis for visual impairment syndrome in space. Aviat Space Environ Med 2014; 85:78–80.

Visual impairment intracranial pressure syndrome (VIIP) is considered a major risk for future human spaceflight. Loss of hydrostatic pressure gradients in vascular and cerebrospinal fluid systems due to the removal of gravity associated with subsequent intracranial and intraocular fluid shifts and the resulting intraocular/intracranial pressure mismatch might be important etiology factors causing VIIP syndrome. Acclimation changes in the ocular and cerebral circulation and the two fluid systems during chronic microgravity exposure and their underlying mechanisms need further elucidation. Relevant findings may help to validate the pressure differential hypothesis for VIIP syndrome and to evaluate whether a gravity based countermeasure is needed.

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Keywords: ISS; VIIP syndrome; microgravity adaptation; visual impairment

Document Type: Commentary

Affiliations: Department of Aerospace Physiology, Fourth Military Medical University, Xi’an, China

Publication date: January 1, 2014

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