Skip to main content
padlock icon - secure page this page is secure

Assessing Psychoactive Pharmaceuticals and Transitioning Pharmacological Fatigue Countermeasures into Operational Environments

Buy Article:

$27.00 + tax (Refund Policy)

Doan BK, Caldwell JA, Hursh SR, Whitmore JN, O’Donnell RD, Russo MB. Assessing psychoactive pharmaceuticals and transitioning pharmacological fatigue countermeasures into operational environments. Aviat Space Environ Med 2005; 76(7, Suppl.):C34-8.

Herein we summarize a discussion on the topic of how psychopharmaceuticals for potential military operational use may be evaluated based on their effects on performance and safety, and introduce two manuscripts: the first (Caldwell and Caldwell; 1) addressing the operational use of fatigue countermeasures; and the second (Rowland; 3) discussing the potential operational use and limitations of ketamine as a field analgesic. Fatigue countermeasures are usually employed by a relatively small number of military members engaged in sustained or continuous operations when sleep is not an option. Clinical treatments are available at any time as required to treat medical conditions. The issue of importance for the operational community, with regard to both clinical use of psychopharmaceuticals and performance maintenance through fatigue countermeasures, should be whether the medication impairs operationally relevant performance, assuming the disorder for which the medication is prescribed does not in itself prohibit operational duties. Applied research paradigms are generally discussed for assessing and transitioning pharmaceutical compounds from the laboratory to the operational environment. Tier 1 focuses on quantifying the impact of stressors and interventions in healthy members of the general population, while Tier 2 testing would use military or operationally matched volunteers in simulated or actual field environments. The section papers address two areas of operational relevance—the Caldwell and Caldwell paper presents guidelines for the use of fatigue countermeasures, and the Rowland paper discusses the potential effects of ketamine, an agent intended to replace morphine as a battlefield analgesic, on cognition.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: fatigue countermeasures; operations; pharmaceuticals; pharmacologic countermeasures; pharmacology; psychotropic

Document Type: Research Article

Publication date: July 1, 2005

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more