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Free Content A Dynamic Rabbit Model of Sinus Barotrauma and Its Related Pathology

BACKGROUND: This study was undertaken to establish a dynamic animal model of sinus barotrauma (SB).

METHODS: The right nasal cavities of 65 rabbits were filled with sponges to obstruct the right ostiomeatal complex (OMC), while in the left nasal cavities, the left OMC was kept clear. The rabbits were exposed to hypobaric chamber simulation. The right sinuses were assigned as the model group, randomly divided into 13 subgroups with 5 in each subgroup, while the left sinuses were assigned as the control group. The hypobaric chamber simulation involved 6 pairs of ascending/descending speeds (100 m · s−1, 75 m · s−1, 50 m · s−1) to 2 altitudes (13,123 ft or 6562 ft). The ascending/descending speed for Model Group 13 was 15 m · s−1 to an altitude of 13,123 ft. The control group was not exposed to hypobaric chamber simulation or obstruction of the OMC. All rabbits were monitored for behavior and via nasal endoscopy, MRI, and mucosal pathology, and statistically analyzed.

RESULTS: SB appeared at the ascending/descending speeds of 50 m · s−1, 75 m · s−1, and 100 m · s−1. SB was more obvious at 100 m · s−1 than at 50 m · s−1 and 75 m · s−1, and SB happened mainly at altitudes between 0-6562 ft. Based on behavior during hypobaric chamber simulation and the results of endoscopic morphology, imaging, and cell pathology, SB could be divided into mild, moderate, and severe.

DISCUSSION: By obstructing the OMC and using hypobaric chamber simulation at high ascending/descending speeds and altitude, a dynamic rabbit model of SB at various degrees was established. The severity of SB was proportional to the ascending/descending speeds and mainly seen below 6562 ft.

Xu X, Wang B, Jin Z, Zhang Y. A dynamic rabbit model of sinus barotrauma and its related pathology. Aerosp Med Hum Perform. 2016; 87(6):521–527.

Keywords: animal; disease models; hypobaric chamber simulation; rabbits

Document Type: Research Article

Affiliations: Center of Clinical Aviation Medicine and Vertigo Clinic Research Center of Aerospace, General Hospital of PLA Air Force, Beijing, China

Publication date: June 1, 2016

More about this publication?
  • This journal (formerly Aviation, Space, and Environmental Medicine), representing the members of the Aerospace Medical Association, is published monthly for those interested in aerospace medicine and human performance. It is devoted to serving and supporting all who explore, travel, work, or live in hazardous environments ranging from beneath the sea to the outermost reaches of space. The original scientific articles in this journal provide the latest available information on investigations into such areas as changes in ambient pressure, motion sickness, increased or decreased gravitational forces, thermal stresses, vision, fatigue, circadian rhythms, psychological stress, artificial environments, predictors of success, health maintenance, human factors engineering, clinical care, and others. This journal also publishes notes on scientific news and technical items of interest to the general reader, and provides teaching material and reviews for health care professionals.

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