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Open Access Estriol; the ‘Good’ Estrogen Advances and Updates in its Clinical Uses

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Estriol, coined the “weaker” of the three endogenous estrogens, has significant therapeutic effects, some of which are little known to clinicians. Estriol provides numerous clinical benefits, commanding the attention of researchers dating as far back as 1966 and continues to garner substantial consideration as a valuable and viable therapeutic agent. Some of the most common and effective treatments that employ estriol include: hot flashes, insomnia, skin enhancement, vaginal atrophy and reduced frequency of urinary tract infections. Most recently, estriol has shown the potential to treat individuals with Th1-mediated autoimmune illnesses, including multiple sclerosis and rheumatoid arthritis. This review article will update the clinical effects and benefits of estriol and further clarify the documented advances which support the substantial therapeutic benefits of estriol for autoimmune conditions. The availability of compounded estriol preparations will also be addressed.
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Keywords: Cytokines; Dendritic cells; Estriol; Menopause; Multiple sclerosis; Rheumatoid arthritis; Th1 autoimmunity

Document Type: Research Article

Publication date: 01 October 2013

More about this publication?
  • JRM is a peer-reviewed medical journal published annually by AARM. It publishes original research, reviews, and editorials that contribute to the understanding of nutritional and botanical influence on underlying mechanisms of chronic illness. The journal was established by MichaĆ«l Friedman, ND as the founding editor. The journal's current editor-in-chief is Liz Sutherland, ND of National University of Natural Medicine.
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