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Retrospective Analysis of Candida-related Conditions in Infancy and Early Childhood Caries

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Purpose: The purpose of this study was to assess whether there is an association between oral thrush or other Candida-related conditions in infancy and early childhood caries (ECC) diagnosed by pediatricians. Methods: We conducted a retrospective cohort study using electronic health records from six national children's hospitals that participate in the PEDSnet research network. There were 1,012,668 children with a visit at ages one to 12 months and another visit at ages 13 to 71 months. The independent variables were diagnosis of thrush or Candida-related conditions in the first year of life, while the dependent variable was diagnosis of ECC between 13 to 71 months old. Results: Oral thrush detection was strongly associated with ECC, particularly between 13 and 36 months (rate ratio between 2.7 [95 percent confidence interval (95% CI) equals 2.5 to 2.9; P<.001] and 3.0 [95% CI, equals 2.8 to 3.4; P<.001]). A similar trend was observed with other Candida-related conditions. Conclusions: Oral thrush may be a risk factor for early childhood caries.
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Keywords: CANDIDA ALBICANS; DENTAL CARIES; TRUSH

Document Type: Research Article

Affiliations: 1: Dental student, in the School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA 2: Second-year dental resident, Division of Pediatric Dentistry, in the School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA 3: Data scientist, Children's Hospital of Philadelphia, Department of Biomedical and Health Informatics, Roberts Center for Pediatric Research, Philadelphia, Pa., USA 4: Associate professor of clinical pediatrics, Children's Hospital of Philadelphia, Division of Hematology/Oncology and Department of Biomedical and Health Informatics, Perelman School of Medicine, Roberts Center for Pediatric Research, Philadelphia 5: Professor of pediatrics, Children's Hospital of Philadelphia, Roberts Center for Pediatric Research, Philadelphia, Pa., USA 6: Chief, Pediatric Dental Division, and director, Pediatric Dentistry Program, Division of Pediatric Dentistry, in the School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA;, Email: [email protected] 7: Professor and director of research, Biofilm Research Labs, Levy Center for Oral Health, Department of Orthodontics, and Pediatric Dentistry and Community of Oral Health Divisions, in the School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA

Publication date: March 1, 2018

More about this publication?
  • Pediatric Dentistry is the official publication of the American Academy of Pediatric Dentistry, the American Board of Pediatric Dentistry and the College of Diplomates of the American Board of Pediatric Dentistry. It is published bi-monthly and is internationally recognized as the leading journal in the area of pediatric dentistry. The journal promotes the practice, education and research specifically related to the specialty of pediatric dentistry. This peer-reviewed journal features scientific articles, case reports and abstracts of current pediatric dental research.
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