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Open Access Effects of Buprenorphine in a Preclinical Orthotopic Tumor Model of Ovarian Carcinoma in Female CB17 SCID Mice

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In the development of cancer therapeutics, no suitable replacements for the use of animals that are capable of modeling such complex disease processes are currently available. In orthotopic models, surgery is often required to access the target organ for tumor cell inoculation. Historically analgesics have been withheld in such models in light of potential effects on tumor development. The current study evaluated the effect of the opioid buprenorphine on tumor growth of a human ovarian cancer cell line (OVCAR5 OT luc2 mCherry). Female CB17 SCID mice (n = 150) underwent surgery for orthotopic inoculation and were assigned to 1 of 3 treatment groups: vehicle control, 1 dose of buprenorphine, or 2 doses of buprenorphine administered perioperatively. Bioluminescence imaging revealed no significant difference on tumor engraftment rate or growth between control and analgesia-treated groups. These data demonstrate that acute, perioperative analgesia with buprenorphine did not alter tumor growth. Although further research is needed to evaluate potential effects of buprenorphine in other cell lines and mouse strains, the justification for withholding analgesia and the potential influence of pain and stress due to insufficient analgesia in these models should be considered thoroughly.
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Document Type: Research Article

Affiliations: 1: Office of Animal Welfare, AbbVie, North Chicago, Illinois; Development Sciences, AbbVie, North Chicago, Illinois;, Email: [email protected] 2: Oncology In Vivo Biology, AbbVie, North Chicago, Illinois; Drug Discovery, AbbVie, North Chicago, Illinois 3: Exploratory Statistics, AbbVie, North Chicago, Illinois; Development Sciences, AbbVie, North Chicago, Illinois 4: Office of Animal Welfare, AbbVie, North Chicago, Illinois; Development Sciences, AbbVie, North Chicago, Illinois 5: Department of Comparative Medicine, AbbVie, North Chicago, Illinois; Development Sciences, AbbVie, North Chicago, Illinois

Publication date: September 1, 2019

This article was made available online on August 14, 2019 as a Fast Track article with title: "Effects of Buprenorphine in a Preclinical Orthotopic Tumor Model of Ovarian Carcinoma in Female CB17 SCID Mice".

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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