@article {Duval:2018:1559-6109:376,
title = "Cardiopulmonary Effects of a Partial Intravenous Anesthesia Technique for Laboratory Swine",
journal = "Journal of the American Association for Laboratory Animal Science",
parent_itemid = "infobike://aalas/jaalas",
publishercode ="aalas",
year = "2018",
volume = "57",
number = "4",
publication date ="2018-07-01T00:00:00",
pages = "376-381",
itemtype = "ARTICLE",
issn = "1559-6109",
eissn = "2769-6677",
url = "https://www.ingentaconnect.com/content/aalas/jaalas/2018/00000057/00000004/art00008",
doi = "doi:10.30802/AALAS-JAALAS-17-000164",
author = "Duval, Justin D and Pang, Jessica M and Boysen, S\oren R and Caulkett, Nigel A",
abstract = "Various anesthetic protocols are used in laboratory swine, each with specific advantages and disadvantages. Partial intravenous anesthetic techniques (PIVA) help minimize dose-dependent cardiopulmonary effects of inhalant drugs. The aim of this study was to determine the cardiopulmonary
effects of a PIVA in laboratory swine. In a prospective, nonrandomized clinical study, 8 healthy juvenile LandraceWhite pigs were premedicated with azaperone (0.20 \textpm 0.20 mg/kg IM), dexmedetomidine (0.02 \textpm 0.002 mg/kg IM), and alfaxalone (2.0 \textpm 0.20 mg/kg IM), and
anesthesia was induced with intravenous alfaxalone. Anesthesia was maintained by using constant-rate infusion of dexmedetomidine (2 g/kg/h) and alfaxalone (25 g/kg/min) in combination with isoflurane. After the fraction of expired isoflurane was adjusted to 1.1% to 1.5%, respiratory
rate, heart rate, systemic and pulmonary arterial pressure, central venous pressure, cardiac output, bispectral index, systemic vascular resistance, and arterial and mixed venous blood gases were recorded every 10 min for 60 min. Statistical analysis consisted of repeated-measures one-way
ANOVA. Significant decreases occurred in heart rate, pulmonary mean arterial pressure, pulmonary diastolic pressure, partial pressure of arterial oxygen, partial pressure of venous oxygen; significant increases occurred in respiratory rate, minute volume index, diastolic arterial blood pressure,
systemic vascular resistance, and arterial pH over time. We consider that the observed statistically significant cardiopulmonary changes were clinically important and that the PIVA protocol provided hemodynamic and respiratory stability for short-term anesthesia of laboratory swine.",
}