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Open Access Suppurative Adenitis of Preputial Glands Associated with Corynebacterium mastitidis Infection in Mice

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Suppuration of the preputial gland in mice occurs as a septic complication of fight wounds around the external genitalia. Currently reported bacterial isolates from these lesions are limited to Staphylococcus aureus, Pasteurella pneumotropica, and Klebsiella oxytoca. In the context of a pilot experiment aimed at defining the aging phenotype of estrogen receptor  knockout (BERKO) mice, 2 male mice (1 of the BERKO line and the other from the age- and sex-matched wild-type control group) were discovered at necropsy to have preputial gland lesions. In both cases, histopathologic examination confirmed severe suppuration and abscesses of the preputial glands associated with systemic reactive (secondary) amyloidosis. Both Gram staining and Bacillus Calmette-Guérin immunohistochemistry highlighted the presence of numerous bacillary to rod-shaped bacteria within the preputial lesions. Subsequent PCR analysis coupled with denaturing gradient gel electrophoresis identified Corynebacterium mastitidis in the preputial gland abscesses. This organism is isolated infrequently from the milk of sheep with subclinical mastitis and was identified as part of the normal microflora of the human ocular surface. No information regarding the epidemiology and pathogenesis of C. mastitidis infection in laboratory animals is currently available, and to our knowledge this report is the first description of C. mastitidis infection in mice.

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Document Type: Case Report

Affiliations: 1: Department of Veterinary Pathology, Hygiene, and Public Health Faculty of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy; Animal Model Systems, Fondazione Filarete, Milan, Italy 2: Department of Veterinary Pathology, Hygiene, and Public Health Faculty of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy 3: DISTAM, Department of Food Science Technology and Microbiology, Università degli Studi di Milano, Milan, Italy 4: Department of Public Health, Veterinary Comparative Pathology and Hygiene, University of Padova, Legnaro, Padua, Italy 5: Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, Università degli Studi di Milano, Milan, Italy 6: Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological Sciences, Università degli Studi di Milano, Milan, Italy; Animal Model Systems, Fondazione Filarete, Milan, Italy

Publication date: January 1, 2010

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

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