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Open Access Preparing for a Semiannual IACUC Inspection of a Satellite Zebrafish (Danio rerio) Facility

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Institutions worldwide have experienced a rapid growth in the use of zebrafish as a research model for a variety of molecular and genetic studies of vertebrate development. This expansion in zebrafish research essentially has outpaced the establishment of specific recommendations for the care and use of fish in research. In some cases, this situation has created a dilemma where an Institutional Animal Care and Use Committee, which is responsible for oversight of vertebrate animal research, is not fully prepared to undertake this role for a decentralized zebrafish facility. IACUC inspectors will be more equipped to ask pertinent questions by understanding the basic principles of zebrafish health and facility management. Concurrently, zebrafish facility managers can contribute to the progress of a semiannual facility inspection by maintaining fully accessible operating records. In the context of presenting a well-established and useful model of zebrafish management and recordkeeping to the zebrafish facility operator, the information we present here also prepares a potential IACUC inspector to conduct a constructive and positive inspection.

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Keywords: GAC, GRANULAR ACTIVATED CARBON; IACUC, INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE; MS222, 3-AMINOBENZOIC ACID ETHYL ESTER (TRICAINE); RO, REVERSE OSMOSIS; SOP, STANDARD OPERATING PROCEDURES; SPF, SPECIFIC PATHOGEN-FREE

Document Type: Research Article

Affiliations: 1: Animal Studies Committee, Washington University, Saint Louis, Missouri 2: Division of Comparative Medicine, School of Medicine, Washington University, Saint Louis, Missouri

Publication date: January 1, 2009

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  • The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.

    Attention Members: To access the full text of the articles, be sure you are logged in to the AALAS website.

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