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Open Access Trends and Treatment Approaches for Complications in Neuroscience Experiments with Monkey Species

Our goal in this manuscript is to advance the assessment and treatment of monkey species in neuroscience research. We hope to begin a discussion and establish baseline data on how complications are identified and treated. We surveyed the neuroscience research community working with monkeys and compiled responses to questions about investigator demographics, assessment of animal wellbeing, treatment choices, and approaches to mitigate risks associated with CNS procedures and promote monkey health and wellbeing. The majority of the respondents had worked with nonhuman primates (NHP) for over 15 y. Identification of procedure-related complications and efficacy of treatment generally rely on common behavioral indices. Treatments for localized inflammatory responses are generally successful, whereas the treatment success for meningitis or meningoencephalitis, abscesses, and hemorrhagic stroke are less successful. Behavioral signs of pain are treated successfully with NSAIDs and opioids. Our future plans are to collate treatment protocols and develop best practices that can be shared across the neuroscience community to improve treatment success rates and animal welfare and therefore science. Human protocols can be used to develop best practices, assess outcomes, and promote further refinements in treatment practices for monkeys to enhance research outcomes.

Document Type: Miscellaneous

Affiliations: 1: Fuster Laboratory of Cognitive Neuroscience, Department of Psychiatry and Biobehavioral Sciences Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California. 2: National Eye Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. 3: Translational Neuroscience Division, Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York; Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University, Mainz, Germany. 4: Department of Experimental Psychology, Oxford University, Tinsley Building, Oxford, United Kingdom; School of Psychology, Speech, and Hearing, University of Canterbury, Christchurch, New Zealand; 5: Fuster Laboratory of Cognitive Neuroscience, Department of Psychiatry and Biobehavioral Sciences Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California; Washington National Primate Research Center, Departments of Biological Structure and Physiology and Biophysics, University of Washington, Seattle, Washington;, Email: [email protected]

Publication date: June 1, 2023

This article was made available online on May 19, 2023 as a Fast Track article with title: "Trends and Treatment Approaches for Complications in Neuroscience Experiments with Monkey Species".

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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