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Open Access Pain as a Clinical Factor and Experimental Variable in Research Rodents

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It is broadly accepted that, as part of the humane care and use of animals in research, the pain experienced by animals should be minimized to the extent possible, consistent with the goals of the research. In some cases, pain may be the subject under study, whereas in other cases, the use of some types of analgesics may interfere with the experimental objectives of the work. This issue of Comparative Medicine provides reviews related to the recognition and treatment of pain, the interaction of pain and pain relief on experimental outcomes, and ethical perspectives on the need to reduce pain in research rodents, whenever possible.

Document Type: Editorial

Affiliations: 1: Office of the Attending Veterinarian, Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky;, Email: [email protected] 2: Global Animal Welfare and Training, Charles River Laboratories, Wilmington, Massachusetts

Publication date: December 1, 2019

This article was made available online on May 30, 2019 as a Fast Track article with title: "Pain as a Clinical Factor and Experimental Variable in Research Rodents".

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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