@article {Szabó:2014:1532-0820:135,
title = "Craniofacial Trauma as a Clinical Marker of Seizures in a Baboon Colony",
journal = "Comparative Medicine",
parent_itemid = "infobike://aalas/cm",
publishercode ="aalas",
year = "2014",
volume = "64",
number = "2",
publication date ="2014-04-01T00:00:00",
pages = "135-139",
itemtype = "ARTICLE",
issn = "1532-0820",
eissn = "2769-819X",
url = "https://www.ingentaconnect.com/content/aalas/cm/2014/00000064/00000002/art00009",
author = "Szab{\’o}, C {\’A}kos and Knape, Koyle D and Leland, M Michelle and Bauer, Cassondra and Williams, Jeff T",
abstract = "Baboons provide a natural model of epilepsy. However, spontaneous seizures are usually sporadic, brief, and may not be observed. We hypothesized that various types of craniofacial trauma (CFT) may serve as reliable markers for epilepsy. We evaluated the type, demographics, and clinical
significance of CFT in a large baboon colony. CFT was categorized according to somatotopic location, propensity to recur, and association with witnessed seizures or abnormal EEG findings. We divided the baboons with CFT into 2 groups: those with known histories of seizures (CFT+Sz, n
= 176) and those without seizure histories (CFTonly; n = 515). In CFT+Sz baboons, the 568 injuries identified included periorbital (57%), scalp (27%), muzzle (12%), and facial (4%) injuries; multiple somatotopic locations or body parts were affected in 21 baboons. The most common CFT
injuries associated with seizures were periorbital and scalp lesions (43% for each region). Compared with those in CFTonly animals, EEG abnormalities, including interictal epileptic discharges (IED) and photosensitivity were more prevalent in the CFT+Sz group, particularly among baboons with
periorbital or scalp injuries. Compared with CFT+Sz animals, CFTonly baboons tended to have later onset and less frequent recurrence of CFT but higher prevalence of muzzle and tooth injuries. IED and photosensitivity were less prevalent in the CFTonly than the CFT+Sz group, with periorbital
injuries carrying the highest and muzzle injuries the lowest association with IED or photosensitivity in both groups. Therefore, CFT in general and periorbital injuries in particular may be markers for seizures in baboons.",
}