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Open Access Spontaneous Coagulopathy in Inbred WAG/RijYcb Rats

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Here we describe a series of cases of spontaneous coagulopathy in a colony of inbred WAG/RijYcb (WAG/RijY) rats. This strain previously had been bred at our institution without symptomatology for several decades. The index case was a 10-wk-old male rat that developed a large hematoma at a subcutaneous injection site. Clinicopathologic findings included a decreased RBC count, decreased hematocrit, decreased hemoglobin concentration, normal PT, and prolonged (50% to 70%) aPTT (52 s; reference, 15 to 33 s). Examination of additional WAG/RijY rats that died unexpectedly or had clinical signs of bleeding in the absence of experimental manipulation also revealed normal PT and prolonged aPTT. Histologic examinations of tissues from all rats were unremarkable except for severe acute focally extensive hemorrhage corresponding to the macroscopic findings of acute hemorrhage. Furthermore the aPTT in 8 clinically normal adult rats and 8 clinically normal 4-wk-old WAG/RijY littermates of both sexes was prolonged. We conclude that these WAG/RijY rats have an inherited defect in the intrinsic coagulation pathway.

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Document Type: Research Article

Affiliations: 1: Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. [email protected] 2: Department of Population Medicine and Diagnostic Sciences, Comparative Coagulation Section, Animal Health Diagnostic Center, Cornell University, Ithaca, New York 3: Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut

Publication date: February 1, 2010

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  • Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.

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