Echocardiographic Features of Pigs with Spontaneous Hypertrophic Cardiomyopathy
Echocardiographic images (2-D) were acquired in parasternal short-axis and long-axis views. The 2-D images provided M-mode under direct anatomic visualization. The pigs were sacrificed for pathologic study after echocardiographic examination. In typical HCM cases (n = 8), the interventricular septum thickness increased, the left ventricular (LV) end-systolic and end-diastolic dimensions decreased, and the left atrial dimensions and the indexes of systolic function, such as ejection fraction and velocity of fiber shortening, increased. The LV outflow tract narrowed, particularly when gross upper septal hypertrophy was evident. Moreover, systolic cranial motion (SCM) of the septal leaflet of the mitral valve was observed. Doppler evidence of mitral regurgitation often was associated with SCM. The echocardiographic findings from pigs with HCM resembled those from humans. Thus, porcine HCM may serve as a spontaneous animal model for the study of HCM in humans.
Document Type: Research Article
Affiliations: 1: Cardiovascular Research Center, Department of Comparative Medicine, Pig Research Institute, Taiwan, Chunan Miaoli Taiwan R.O.C.; Department of Veterinary Medicine, National Taiwan University, Taipei, R.O.C. 2: Cardiovascular Research Center, Department of Comparative Medicine, Pig Research Institute, Taiwan, Chunan Miaoli Taiwan R.O.C. 3: Department of Pathology, The Animal Medical Center, New York, New York
Publication date: June 1, 2002
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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