Fatal Lymphoproliferative Disease Associated with a Novel Gammaherpesvirus in a Captive Population of Common Marmosets
Methods: Marmosets in the colony were subjected to histologic examination and serologic testing for EpsteinBarr virus (EBV). The DNA from tumors that developed in the marmosets was subjected to consensus primer polymerase chain reaction (PCR) analysis designed to amplify conserved regions of herpesvirus genomes.
Results: The mesenteric lymph nodes and intestinal mucosa were consistently infiltrated by principally B lymphocytes, which often obliterated the normal architecture. Of 84 clinically normal marmosets, 52 were seropositive for EBV. The tumor DNA contained previously unreported herpesvirus sequences closely related to but distinct from those of EBV, Herpesvirus papio, and these lymphocryptovirus, a novel gammaherpesvirus. Results of PCR analysis of circulating lymphocytes from EBV-positive, clinically normal marmosets were negative for EBV antibodies and were positive for marmoset lymphocryptovirus; PCR analysis of circulating lymphocytes from EBVnegative marmosets yielded negative results for EBV and this novel marmoset lymphocryptovirus.
Conclusion: This novel gammaherpesvirus possibly associated with tumor development may have important management implications for captive callitrichids.
Document Type: Research Article
Affiliations: 1: The Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 2: PathoGenesis Corporation, Seattle, Washington 3: U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland
Publication date: February 1, 2000
Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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