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The ORL-1 Receptor System: Are There Opportunities for Antagonists in Pain Therapy?

Authors: Fioravanti, Beatriz; Vanderah, Todd W.

Source: Current Topics in Medicinal Chemistry, Volume 8, Number 16, November 2008 , pp. 1442-1451(10)

Publisher: Bentham Science Publishers

The Pharmacology of Ro 64-6198, a Systemically Active, Nonpeptide NOP Receptor (Opiate Receptor-Like 1, ORL-1) Agonist with Diverse Preclinical Therapeutic Activity

Author: Shoblock, James R.

Source: CNS Drug Reviews, Volume 13, Number 1, March 2007 , pp. 107-136(30)

Publisher: Blackwell Publishing

8-(Heteroaryl)phenalkyl-1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as Opioid Receptor Modulators

Authors: Jordan, A. D.; Orsini, M. J.; Middleton, S. A.; Connolly, P. J.; Brenneman, D. E.; Pan, K.; Reitz, A. B.

Source: Medicinal Chemistry, Volume 1, Number 6, November 2005 , pp. 601-610(10)

Publisher: Bentham Science Publishers

Recent advances towards the discovery of ORL-1 receptor agonists and antagonists

Authors: Bignan, Gilles C; Connolly, Peter J; Middleton, Steven A

Source: Expert Opinion on Therapeutic Patents, Volume 15, Number 4, 1 April 2005 , pp. 357-388(32)

Publisher: Informa Healthcare

G Protein-Coupled Receptor Structural Motifs: Relevance to the Opioid Receptors

Authors: Surratt, Christopher K.; Adams, Wendy R.

Source: Current Topics in Medicinal Chemistry, Volume 5, Number 3, April 2005 , pp. 315-324(10)

Publisher: Bentham Science Publishers

Buprenorphine: A Unique Drug with Complex Pharmacology

Authors: Kabirullah Lutfy; Alan Cowan

Source: Current Neuropharmacology, Volume 2, Number 4, October 2004 , pp. 395-402(8)

Publisher: Bentham Science Publishers

Nociceptin/orphanin FQ modulates spatial learning via ORL-1 receptors in the dorsal hippocampus of the rat

Authors: Sandin J.; Ogren S.O.; Terenius L.

Source: Brain Research, Volume 997, Number 2, 6 February 2004 , pp. 222-233(12)

Publisher: Elsevier

Distribution of ORL-1 receptor binding and receptor-activated G-proteins in rat forebrain and their experimental localization in anterior cingulate cortex

Authors: Sim-Selley L.J.; Vogt L.J.; Childers S.R.; Vogt B.A.

Source: Neuropharmacology, Volume 45, Number 2, August 2003 , pp. 220-230(11)

Publisher: Elsevier

Visualizing activation of opioid circuits by internalization of G protein-coupled receptors

Authors: Sinchak, Kevin; Micevych, Paul

Source: Molecular Neurobiology, Volume 27, Number 2, April 2003 , pp. 197-222(26)

Publisher: Humana Press

Peripheral effects of opioids and nociceptin in neuropathic pain

Authors: Obara, I.; Starowicz, K.; Bilecki, W.; Przewłocki, R.; Przewłocka, B.

Source: Journal of Neurochemistry, Volume 85, Supplement 2, June 2003 , pp. 31-31(1)

Publisher: Blackwell Publishing

Involvement of the Neuropeptide Orphanin FQ/Nociceptin in Kainate and Kindling Seizures and Epileptogenesis

Authors: Bregola, G.; Zucchini, S.; Frigati, L.; Candeletti, S.; Romualdi, P.; Reinscheid, R.; Simonato, M.

Source: Epilepsia, Volume 43, Supplement 5, June 2002 , pp. 18-19(2)

Publisher: Blackwell Publishing

The ORL-1 (NOP₁) receptor ligand nociceptin/orphanin FQ (N/OFQ) inhibits neurogenic dural vasodilatation in the rat

Authors: Bartsch T.; Akerman S.; Goadsby P.J.

Source: Neuropharmacology, Volume 43, Number 6, November 2002 , pp. 991-998(8)

Publisher: Elsevier

Influence of a deletion of protein kinase C isoform in the G-protein activation mediated through opioid receptor-like-1 and -opioid receptors in the mouse pons/medulla

Authors: Narita M.; Mizoguchi H.; Khotib J.; Suzuki M.; Ozaki S.; Yajima Y.; Narita M.; Tseng L.F.; Suzuki T.

Source: Neuroscience Letters, Volume 331, Number 1, 4 October 2002 , pp. 5-8(4)

Publisher: Elsevier

Corrigendum to ''Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury'' [Eur. J. Pharmacol. 447 (2002) 59-65]

Authors: Briscini L.; Corradini L.; Ongini E.; Bertorelli R.

Source: European Journal of Pharmacology, Volume 450, Number 1, 16 August 2002 , pp. 113-113(1)

Publisher: Elsevier

Lack of the nociceptin receptor does not affect acute or chronic nociception in mice

Authors: Bertorelli R.; Bastia E.; Citterio F.; Corradini L.; Forlani A.; Ongini E.

Source: Peptides, Volume 23, Number 9, September 2002 , pp. 1589-1596(8)

Publisher: Elsevier

Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury

Authors: Briscini L.; Corradini L.; Ongini E.; Bertorelli R.

Source: European Journal of Pharmacology, Volume 447, Number 1, 28 June 2002 , pp. 59-65(7)

Publisher: Elsevier

Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization

Authors: Dong X.-W.; Williams P.A.; Jia Y.-P.; Priestley T.

Source: Pain, Volume 96, Number 3, April 2002 , pp. 309-318(10)

Publisher: Elsevier

Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats

Authors: Ciccocioppo R.; Polidori C.; Antonelli L.; Salvadori S.; Guerrini R.; Massi M.

Source: Peptides, Volume 23, Number 1, January 2002 , pp. 117-125(9)

Publisher: Elsevier

Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe¹)nociceptin(1-13)NH₂

Authors: Bytner B.; Huang Y.-H.; Yu L.-C.; Lundeberg T.; Nylander I.; Rosen A.

Source: Brain Research, Volume 922, Number 1, 13 December 2001 , pp. 118-124(7)

Publisher: Elsevier

The putative OP₄ antagonist, [Nphe¹]nociceptin(1-13)NH₂, prevents the effects of nociceptin in neuropathic rats

Authors: Corradini L.; Briscini L.; Ongini E.; Bertorelli R.

Source: Brain Research, Volume 905, Number 1, 29 June 2001 , pp. 127-133(7)

Publisher: Elsevier