IngentaConnect Search Results

C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes

Authors: Zhang, Y.-Y.; Liu, Y.; Zhang, J.-W.; Ge, G.-B.; Liu, H.-X.; Wang, L.-M.; Sun, J.; Yang, L.

Source: Xenobiotica, Volume 39, Number 12, December 2009 , pp. 903-914(12)

Publisher: Informa Healthcare

Structure-activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases

Authors: Wong, Yin Cheong; Zhang, Li; Lin, Ge; Zuo, Zhong

Source: Expert Opinion on Drug Metabolism and Toxicology, Volume 5, Number 11, November 2009 , pp. 1399-1419(21)

Publisher: Informa Healthcare

Effects of ozone exposure on the oxidative capacity for drug biotransformation in Wistar rats

Authors: Lares-Asseff, Ismael; Fernandez Saavedra, Gabriela; Toledo, Alejandra; Sosa Macias, Martha; Bradley, Francisco; Espinosa, Javier

Source: Toxicological and Environmental Chemistry, Volume 91, Number 4, June 2009 , pp. 707-716(10)

Publisher: Taylor and Francis Ltd

The Role of Human CYP2C8 and CYP2C9 Variants in Pioglitazone Metabolism In Vitro

Authors: Muschler, Eugen; Lal, Jawahar; Jetter, Alexander; Rattay, Anke; Zanger, Ulrich; Zadoyan, Gregor; Fuhr, Uwe; Kirchheiner, Julia

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 6, December 2009 , pp. 374-379(6)

Publisher: Blackwell Publishing

Roles of Different CYP Enzymes in the Formation of Specific Fluvastatin Metabolites by Human Liver Microsomes

Authors: Toda, Takaki; Eliasson, Erik; Ask, Birgitta; Inotsume, Nobuo; Rane, Anders

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 5, November 2009 , pp. 327-332(6)

Publisher: Blackwell Publishing

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca²⁺ pump

Authors: Tazzeo, T; Worek, F; Janssen, LJ

Source: British Journal of Pharmacology, Volume 158, Number 3, October 2009 , pp. 790-796(7)

Publisher: Blackwell Publishing

In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation

Authors: Chetty, Manoranjenni; d'Esposito, Fabrizio; Zhang, Wei V.; Glen, John; Dore, Glenys; Stankovic, Zvijezdana; Edwards, Robert J.; Ramzan, Iqbal; Murray, Michael

Source: British Journal of Clinical Pharmacology, Volume 68, Number 4, October 2009 , pp. 574-579(6)

Publisher: Blackwell Publishing

Determination of Naloxone and Nornaloxone (Noroxymorphone) by High-Performance Liquid Chromatography-Electrospray Ionization- Tandem Mass Spectrometry

Authors: Fang, Wenfang B.; Chang, Yan; McCance-Katz, Elinore F.; Moody, David E.

Source: Journal of Analytical Toxicology, Volume 33, Number 8, October 2009 , pp. 409-417(9)

Publisher: Preston Publications

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4′-methanol-bisbenzonitrile in vitro

Authors: Jeong, Seongwook; Woo, Margaret; Flockhart, David; Desta, Zeruesenay

Source: Cancer Chemotherapy and Pharmacology, Volume 64, Number 5, October 2009 , pp. 867-875(9)

Publisher: Springer

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Authors: Murai, K.; Yamazaki, H.; Nakagawa, K.; Kawai, R.; Kamataki, T.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 795-802(8)

Publisher: Informa Healthcare

Metabolite screening of aromatic amine hair dyes using in vitro hepatic models

Authors: Skare, J. A.; Hewitt, N. J.; Doyle, E.; Powrie, R.; Elcombe, C.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 811-825(15)

Publisher: Informa Healthcare

Studies on induction of lamotrigine metabolism in transgenic UGT1 mice

Authors: Argikar, U. A.; Senekeo-Effenberger, K.; Larson, E. E.; Tukey, R. H.; Remmel, R. P.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 826-835(10)

Publisher: Informa Healthcare

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Authors: Nishiya, Y.; Hagihara, K.; Kurihara, A.; Okudaira, N.; Farid, N.A.; Okazaki, O.; Ikeda, T.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 836-843(8)

Publisher: Informa Healthcare

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

Authors: Wong, H.; Chen, J.Z.; Chou, B.; Halladay, J.S.; Kenny, J.R.; La, H.; Marsters, J.C.; Plise, E.; Rudewicz, P.J.; Robarge, K.; Shin, Y.; Wong, S.; Zhang, C.; Khojasteh, S.C.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 850-861(12)

Publisher: Informa Healthcare

In-vitro and in-vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry

Authors: Gorman, Gregory S.; Coward, Lori; Kerstner-Wood, Corenna; Freeman, Lea; Hebert, Charles D.; Kapetanovic, Izet M.

Source: Journal of Pharmacy and Pharmacology, Volume 61, Number 10, October 2009 , pp. 1309-1318(10)

Publisher: Pharmaceutical Press

Authors: Fonsi, M.; Fiore, F.; Jones, P.; Kinzel, O.; Laufer, R.; Rowley, M.; Monteagudo, E.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 722-737(16)

Publisher: Informa Healthcare

Metabolic interactions between prokinetic agents domperidone and erythromycin: an in vitro analysis

Authors: Ung, D.; Parkman, H. P.; Nagar, S.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 749-756(8)

Publisher: Informa Healthcare

Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506)

Authors: Tata, P. N. V.; Subbotina, N.; Burckart, G. J.; Muddiman, D. C.; Gusev, A. I.; Hercules, D. M.; Starzl, T. E.; Venkataramanan, R.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 757-765(9)

Publisher: Informa Healthcare

Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

Authors: Frederick, K.S.; Maurer, T.S.; Kalgutkar, A.S.; Royer, L.J.; Francone, O.L.; Winter, S.M.; Terra, S.G.; Chen, D.; Gao, X.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 766-781(16)

Publisher: Informa Healthcare

Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDs

Authors: Knights, Kathleen M.; Winner, Leanne K.; Elliot, David J.; Bowalgaha, Kushari; Miners, John O.

Source: British Journal of Clinical Pharmacology, Volume 68, Number 3, September 2009 , pp. 402-412(11)

Publisher: Blackwell Publishing