Search Results

Disease-Modifying Approach to the Treatment of Alzheimer's Disease: From α-Secretase Activators to γ-Secretase Inhibitors and Modulators

Authors: Panza, Francesco; Solfrizzi, Vincenzo; Frisardi, Vincenza; Capurso, Cristiano; D'Introno, Alessia; Colacicco, Anna M.; Vendemiale, Gianluigi; Capurso, Antonio; Imbimbo, Bruno P.

Source: Drugs & Aging, Volume 26, Number 7, 1 July 2009 , pp. 537-555(19)

Publisher: Adis International

Cell biology, regulation and inhibition of β-secretase (BACE-1)

Authors: Hunt, Clare E.; Turner, Anthony J.

Source: FEBS Journal, Volume 276, Number 7, April 2009 , pp. 1845-1859(15)

Publisher: Blackwell Publishing

Beta-Secretase: Structure, Function, and Evolution

Authors: Venugopal, Chitra; Demos, Christina M.; Jagannatha Rao, K. S.; Pappolla, Miguel A.; Sambamurti, Kumar

Source: CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets, Volume 7, Number 3, June 2008 , pp. 278-294(17)

Publisher: Bentham Science Publishers

Editorial [ Production and Fate of Amyloid Peptides: Recent Advances and Perspectives ]

Author: Checler, Frederic

Source: Current Alzheimer Research, Volume 5, Number 2, April 2008 , pp. 90-91(2)

Publisher: Bentham Science Publishers

Memapsin 2 (Beta-Secretase) Inhibitors: Drug Development

Authors: Ghosh, Arun K.; Kumaragurubaran, Nagaswamy; Hong, Ling; Koelsh, Gerald; Tang, Jordan

Source: Current Alzheimer Research, Volume 5, Number 2, April 2008 , pp. 121-131(11)

Publisher: Bentham Science Publishers

Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality

Authors: Ghosh, Arun K.; Bilcer, Geoffrey; Hong, Lin; Koelsch, Gerald; Tang, Jordan

Source: Current Alzheimer Research, Volume 4, Number 4, September 2007 , pp. 418-422(5)

Publisher: Bentham Science Publishers

Recent Developments of Structure Based β-Secretase Inhibitors for Alzheimer's Disease

Authors: Ghosh, Aurn K.; Kumaragurubaran, Nagaswamy; Tang, Jordan

Source: Current Topics in Medicinal Chemistry, Volume 5, Number 16, December 2005 , pp. 1609-1622(14)

Publisher: Bentham Science Publishers

Recent Developments on the Studies of Human Memapsin 2 (-Secretase)

Authors: Tang, Jordan; He, Xiangyang; Huang, Xianping; Hong, Lin

Source: Current Alzheimer Research, Volume 2, Number 2, April 2005 , pp. 261-264(4)

Publisher: Bentham Science Publishers

Inhibition of BACE-1 by Hydroxyethylsulfide, Hydroxyethylamine and Hydroxyethylurea Isosteric Replacements

Authors: L. Rizzi; S. Romeo

Source: Letters in Drug Design & Discovery, Volume 2, Number 2, March 2005 , pp. 109-112(4)

Publisher: Bentham Science Publishers

Amyloid precursor protein compartmentalization restricts β-amyloid production: Therapeutic targets based on BACE compartmentalization

Authors: Gandhi, Swetal; Refolo, Lorenzo; Sambamurti, Kumar

Source: Journal of Molecular Neuroscience, Volume 24, Number 1, February 2004 , pp. 137-143(7)

Publisher: Humana Press

In vivo inhibition of A production by memapsin 2 (-secretase) inhibitors

Authors: Chang W-P.; Koelsch G.; Wong S.; Downs D.; Da H.; Weerasena V.; Gordon B.; Devasamudram T.; Bilcer G.; Ghosh A.K.; Tang J.

Source: Journal of Neurochemistry, Volume 89, Number 6, June 2004 , pp. 1409-1416(8)

Publisher: Blackwell Publishing

BACE1: The -Secretase Enzyme in Alzheimer's Disease

Author: Vassar Robert

Source: Journal of Molecular Neuroscience, Volume 23, Numbers 1-2, April 2004 , pp. 105-114(10)

Publisher: Humana Press

β-secretase processing of the Alzheimer's amyloid protein precursor (APP)

Authors: Marlow, Laura; Cain, Melissa; Pappolla, Miguel; Sambamurti, Kumar

Source: Journal of Molecular Neuroscience, Volume 20, Number 3, August 2003 , pp. 233-239(7)

Publisher: Humana Press

Study of memapsin 2 (β-secretase) and strategy of inhibitor design

Authors: Tang, Jordan; Ghosh, Arun; Hong, Lin; Koelsch, Gerald; Turner, Robert; Chang, Wanpin

Source: Journal of Molecular Neuroscience, Volume 20, Number 3, August 2003 , pp. 299-304(6)

Publisher: Humana Press

Quantification and distribution of -secretase alternative splice variants in the rat and human brain

Authors: Zohar O.; Cavallaro S.; D'Agata V.; Alkon D.L.

Source: Molecular Brain Research, Volume 115, Number 1, 4 July 2003 , pp. 63-68(6)

Publisher: Elsevier

The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity

Authors: Fischer, Frauke; Molinari, Maurizio; Bodendorf, Ursula; Paganetti, Paolo

Source: Journal of Neurochemistry, Volume 80, Number 6, March 2002 , pp. 1079-1088(10)

Publisher: Blackwell Publishing

Expression of human β-secretase in the mouse brain increases the steady-state level of β-amyloid

Authors: Bodendorf, Ursula; Danner, Simone; Fischer, Frauke; Stefani, Muriel; Sturchler-Pierrat, Christine; Wiederhold, Karl-Heinz; Staufenbiel, Matthias; Paganetti, Paolo

Source: Journal of Neurochemistry, Volume 80, Number 5, March 2002 , pp. 799-806(8)

Publisher: Blackwell Publishing

Localization of -Secretase Memapsin 2 in the Brain of Alzheimer's Patients and Normal Aged Controls

Authors: Sun A.; Koelsch G.; Tang J.; Bing G.

Source: Experimental Neurology, Volume 175, Number 1, May 2002 , pp. 10-22(13)

Publisher: Elsevier

Prediction of the Tertiary Structure of the -Secretase Zymogen

Authors: Chou K.-C.; Howe W.J.

Source: Biochemical and Biophysical Research Communications, Volume 292, Number 3, 5 April 2002 , pp. 702-708(7)

Publisher: Elsevier

Erratum to: Memapsin 2 (-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2 (FEBS 26327) - [FEBS Letters 524 (2002) 183-187]

Authors: He X.; Chang W.-P.; Koelsch G.; Tang J.

Source: FEBS Letters, Volume 526, Number 1, 28 August 2002 , pp. 152-152(1)

Publisher: Elsevier