IngentaConnect Search Results

C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes

Authors: Zhang, Y.-Y.; Liu, Y.; Zhang, J.-W.; Ge, G.-B.; Liu, H.-X.; Wang, L.-M.; Sun, J.; Yang, L.

Source: Xenobiotica, Volume 39, Number 12, December 2009 , pp. 903-914(12)

The Role of Human CYP2C8 and CYP2C9 Variants in Pioglitazone Metabolism In Vitro

Authors: Muschler, Eugen; Lal, Jawahar; Jetter, Alexander; Rattay, Anke; Zanger, Ulrich; Zadoyan, Gregor; Fuhr, Uwe; Kirchheiner, Julia

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 6, December 2009 , pp. 374-379(6)

Publisher: Blackwell Publishing

Roles of Different CYP Enzymes in the Formation of Specific Fluvastatin Metabolites by Human Liver Microsomes

Authors: Toda, Takaki; Eliasson, Erik; Ask, Birgitta; Inotsume, Nobuo; Rane, Anders

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 5, November 2009 , pp. 327-332(6)

Publisher: Blackwell Publishing

In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation

Authors: Chetty, Manoranjenni; d'Esposito, Fabrizio; Zhang, Wei V.; Glen, John; Dore, Glenys; Stankovic, Zvijezdana; Edwards, Robert J.; Ramzan, Iqbal; Murray, Michael

Source: British Journal of Clinical Pharmacology, Volume 68, Number 4, October 2009 , pp. 574-579(6)

Publisher: Blackwell Publishing

Determination of Naloxone and Nornaloxone (Noroxymorphone) by High-Performance Liquid Chromatography-Electrospray Ionization- Tandem Mass Spectrometry

Authors: Fang, Wenfang B.; Chang, Yan; McCance-Katz, Elinore F.; Moody, David E.

Source: Journal of Analytical Toxicology, Volume 33, Number 8, October 2009 , pp. 409-417(9)

Publisher: Preston Publications

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4′-methanol-bisbenzonitrile in vitro

Authors: Jeong, Seongwook; Woo, Margaret; Flockhart, David; Desta, Zeruesenay

Source: Cancer Chemotherapy and Pharmacology, Volume 64, Number 5, October 2009 , pp. 867-875(9)

Publisher: Springer

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Authors: Murai, K.; Yamazaki, H.; Nakagawa, K.; Kawai, R.; Kamataki, T.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 795-802(8)

Publisher: Informa Healthcare

Metabolite screening of aromatic amine hair dyes using in vitro hepatic models

Authors: Skare, J. A.; Hewitt, N. J.; Doyle, E.; Powrie, R.; Elcombe, C.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 811-825(15)

Publisher: Informa Healthcare

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Authors: Nishiya, Y.; Hagihara, K.; Kurihara, A.; Okudaira, N.; Farid, N.A.; Okazaki, O.; Ikeda, T.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 836-843(8)

Publisher: Informa Healthcare

Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor

Authors: Wong, H.; Chen, J.Z.; Chou, B.; Halladay, J.S.; Kenny, J.R.; La, H.; Marsters, J.C.; Plise, E.; Rudewicz, P.J.; Robarge, K.; Shin, Y.; Wong, S.; Zhang, C.; Khojasteh, S.C.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 850-861(12)

Publisher: Informa Healthcare

Authors: Fonsi, M.; Fiore, F.; Jones, P.; Kinzel, O.; Laufer, R.; Rowley, M.; Monteagudo, E.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 722-737(16)

Publisher: Informa Healthcare

Metabolic interactions between prokinetic agents domperidone and erythromycin: an in vitro analysis

Authors: Ung, D.; Parkman, H. P.; Nagar, S.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 749-756(8)

Publisher: Informa Healthcare

Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506)

Authors: Tata, P. N. V.; Subbotina, N.; Burckart, G. J.; Muddiman, D. C.; Gusev, A. I.; Hercules, D. M.; Starzl, T. E.; Venkataramanan, R.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 757-765(9)

Publisher: Informa Healthcare

Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

Authors: Frederick, K.S.; Maurer, T.S.; Kalgutkar, A.S.; Royer, L.J.; Francone, O.L.; Winter, S.M.; Terra, S.G.; Chen, D.; Gao, X.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 766-781(16)

Publisher: Informa Healthcare

Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: Inhibition by NSAIDs

Authors: Knights, Kathleen M.; Winner, Leanne K.; Elliot, David J.; Bowalgaha, Kushari; Miners, John O.

Source: British Journal of Clinical Pharmacology, Volume 68, Number 3, September 2009 , pp. 402-412(11)

Publisher: Blackwell Publishing

Isolation of two cytochrome P450 forms, CYP2A19 and CYP1A, from pig liver microsomes

Authors: MATAL, J.; TUNKOVÁ, A.; ŠILLER, M.; ANZENBACHEROVÁ, E.; ANZENBACHER, P.

Source: Journal of Veterinary Pharmacology & Therapeutics, Volume 32, Number 5, October 2009 , pp. 470-476(7)

Publisher: Blackwell Publishing

CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes

Authors: Liu, H.-X.; Hu, Y.; Liu, Y.; He, Y.-Q.; Li, W.; Yang, L.

Source: Xenobiotica, Volume 39, Number 9, September 2009 , pp. 672-679(8)

Publisher: Informa Healthcare

Determination of 4-Hydroxy-3-methoxymethamphetamine as a Metabolite of Methamphetamine in Rats and Human Liver Microsomes Using Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry

Authors: Kuwayama, Kenji; Tsujikawa, Kenji; Miyaguchi, Hajime; Kanamori, Tatsuyuki; Iwata, Yuko T.; Inoue, Hiroyuki

Source: Journal of Analytical Toxicology, Volume 33, Number 5, June 2009 , pp. 266-271(6)

Publisher: Preston Publications

Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects

Authors: Ushijima, Kentarou; Tsuruoka, Shu-ichi; Tsuda, Hidetoshi; Hasegawa, Gohki; Obi, Yuri; Kaneda, Tae; Takahashi, Masaki; Maekawa, Tomohiro; Sasaki, Tomohiro; Koshimizu, Taka-aki; Fujimura, Akio

Source: British Journal of Clinical Pharmacology, Volume 68, Number 2, August 2009 , pp. 194-200(7)

Publisher: Blackwell Publishing

Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism

Authors: Doki, Kosuke; Homma, Masato; Kuga, Keisuke; Aonuma, Kazutaka; Kohda, Yukinao

Source: British Journal of Clinical Pharmacology, Volume 68, Number 1, July 2009 , pp. 89-96(8)

Publisher: Blackwell Publishing