Search Results

Design, Synthesis and Preliminary Screening of Some New Conformationally Constrained Falcipain-2 Inhibitors as Potential Antimalarial Agents

Authors: Shinde, Anil K.; Chouhan, Bishram S.; Dasgupta, Shirshendu; Giridhar, Rajani; Rosenthal, Philip; Gut, Jiri; Yadav, Mange R.

Source: Letters in Drug Design & Discovery, Volume 6, Number 4, June 2009 , pp. 258-267(10)

Publisher: Bentham Science Publishers

Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases

Authors: Redzynia, Izabela; Ljunggren, Anna; Bujacz, Anna; Abrahamson, Magnus; Jaskolski, Mariusz; Bujacz, Grzegorz

Source: FEBS Journal, Volume 276, Number 3, February 2009 , pp. 793-806(14)

Publisher: Blackwell Publishing

Malarial proteases and host cell egress: an `emerging' cascade

Author: Blackman, Michael J.

Source: Cellular Microbiology, Volume 10, Number 10, October 2008 , pp. 1925-1934(10)

Publisher: Blackwell Publishing

A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2

Authors: Singh, Ajay; Walker, K. Jordan; Sijwali, Puran S.; Lau, Anthony L.; Rosenthal, Philip J.

Source: Protein Engineering, Design and Selection, Volume 20, Number 4, 12 APRIL 2007 , pp. 171-177(7)

Publisher: Oxford University Press

Responsiveness of parasite Cys His proteases to iron redox

Author: Lockwood, Thomas

Source: Parasitology Research, Volume 100, Number 1, December 2006 , pp. 175-181(7)

Publisher: Springer

Cysteine Proteinase Inhibitors as Therapy for Parasitic Diseases: Advances in Inhibitor Design

Authors: Steverding, Dietmar; Caffrey, Conor R.; Sajid, Mohammed

Source: Mini Reviews in Medicinal Chemistry, Volume 6, Number 9, September 2006 , pp. 1025-1032(8)

Publisher: Bentham Science Publishers

Location, Location, Location: Trafficking and Function of Secreted Proteases of Toxoplasma and Plasmodium

Authors: Emily M. Binder; Kami Kim

Source: Traffic, Volume 5, Number 12, December 2004 , pp. 914-924(11)

Publisher: Blackwell Publishing

Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

Authors: Eksi, Saliha; Czesny, Beata; Greenbaum, Doron C.; Bogyo, Matthew; Williamson, Kim C.

Source: Molecular Microbiology, Volume 53, Number 1, July 2004 , pp. 243-250(8)

Publisher: Blackwell Publishing

Soluble expression of a functionally active Plasmodium falciparum falcipain-2 fused to maltose-binding protein in Escherichia coli

Authors: Goh L.L.; Loke P.; Singh M.; Sim T.S.

Source: Protein Expression and Purification, Volume 32, Number 2, December 2003 , pp. 194-201(8)

Publisher: Elsevier

The Synthesis of Parasitic Cysteine Protease and Trypanothione Reductase Inhibitors

Authors: Chibale Kelly; Musonda Chitalu C.

Source: Current Medicinal Chemistry, Volume 10, Number 18, September 2003 , pp. 1863-1889(27)

Publisher: Bentham Science Publishers

Original Article
Gene Conversion as a Source of Nucleotide Diversity in Plasmodium falciparum

Authors: Nielsen K.M.; Kasper J.; Choi M.; Bedford T.; Kristiansen K.; Wirth D.F.; Volkman S.K.; Lozovsky E.R.; Hartl D.L.

Source: Molecular Biology and Evolution, Volume 20, Number 5, May 2003 , pp. 726-734(9)

Publisher: Oxford University Press

Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-Trisubstituted dihydroisoquinolines and isoquinolines

Authors: Batra S.; Sabnis Y.A.; Rosenthal P.J.; Avery M.A.

Source: Bioorganic and Medicinal Chemistry, Volume 11, Number 10, 15 May 2003 , pp. 2293-2299(7)

Publisher: Elsevier

Double-stranded RNA-mediatedgene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum

Authors: Malhotra, Pawan; Dasaradhi, Palakodeti V. N.; Kumar, Amit; Mohmmed, Asif; Agrawal, Neema; Bhatnagar, Raj K.; Chauhan, Virander S.

Source: Molecular Microbiology, Volume 45, Number 5, September 2002 , pp. 1245-1254(10)

Publisher: Blackwell Publishing

Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases

Authors: Shenai B.R.; Rosenthal P.J.

Source: Molecular and Biochemical Parasitology, Volume 122, Number 1, June 2002 , pp. 99-104(6)

Publisher: Elsevier

Cysteine Proteases of Malaria Parasites: Targets for Chemotherapy

Authors: Rosenthal, P.J.; Sijwali, P.S.; Singh, A.; Shenai, B.R.

Source: Current Pharmaceutical Design, Volume 8, Number 18, 1 August 2002 , pp. 1659-1672(14)

Publisher: Bentham Science Publishers

Thiol-Dependent Enzymes and Their Inhibitors: A Review

Authors: Leung-Toung R.; Li W.; Tam T.F.; Kaarimian K.

Source: Current Medicinal Chemistry, Volume 9, Number 9, May 2002 , pp. 979-1002(24)

Publisher: Bentham Science Publishers

Systematic Optimization of Expression and Refolding of the Plasmodium falciparum Cysteine Protease Falcipain-2

Authors: Sijwali P.S.; Brinen L.S.; Rosenthal P.J.

Source: Protein Expression and Purification, Volume 22, Number 1, June 2001 , pp. 128-134(7)

Publisher: Elsevier

Synthesis of quinolinyl chalcones and evaluation of their antimalarial activity

Authors: Domnguez J.N.; Charris J.E.; Lobo G.; Gamboa de Domnguez N.; Moreno M.M.; Riggione F.; Sanchez E.; Olson J.; Rosenthal P.J.

Source: European Journal of Medicinal Chemistry, Volume 36, Number 6, June 2001 , pp. 555-560(6)

Publisher: Elsevier

Recombinant falcipain-2 cleaves erythrocyte membrane ankyrin and protein 4.1

Authors: Dua M.; Raphael P.; Sijwali P.S.; Rosenthal P.J.; Hanspal M.

Source: Molecular and Biochemical Parasitology, Volume 116, Number 1, August 2001 , pp. 95-99(5)

Publisher: Elsevier

Inhibition of Cysteine Protease Activity by NO-donors

Authors: Ascenzi P.; Salvati L.; Bolognesi M.; Colasanti M.; Polticelli F.; Venturini G.

Source: Current Protein and Peptide Science, Volume 2, Number 2, June 2001 , pp. 137-153(17)

Publisher: Bentham Science Publishers