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New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives

Authors: Rivera, Gildardo; Bocanegra-Garcia, Virgilio; Ordaz-Pichardo, Cynthia; Nogueda-Torres, Benjamin; Monge, Antonio

Source: Current Medicinal Chemistry, Volume 16, Number 25, September 2009 , pp. 3286-3293(8)

Publisher: Bentham Science Publishers

Approaches for the Development of New Anti-Trypanosoma cruzi Agents

Authors: Magalhaes Moreira, Diogo Rodrigo; Lima Leite, Ana C.; Santos, Ricardo Ribeiro d.o.s.; Soares, Milena B.P.

Source: Current Drug Targets, Volume 10, Number 3, March 2009 , pp. 212-231(20)

Publisher: Bentham Science Publishers

Structure-activity relationships for a class of selective inhibitors of the major cysteine protease from Trypanosoma cruzi

Authors: Guido, Rafael; Trossini, Gustavo; Castilho, Marcelo; Oliva, Glaucius; Ferreira, Elizabeth; Andricopulo, Adriano

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 23, Number 6, December 2008 , pp. 964-973(10)

Publisher: Informa Healthcare

Responsiveness of parasite Cys His proteases to iron redox

Author: Lockwood, Thomas

Source: Parasitology Research, Volume 100, Number 1, December 2006 , pp. 175-181(7)

Publisher: Springer

Cysteine Proteinase Inhibitors as Therapy for Parasitic Diseases: Advances in Inhibitor Design

Authors: Steverding, Dietmar; Caffrey, Conor R.; Sajid, Mohammed

Source: Mini Reviews in Medicinal Chemistry, Volume 6, Number 9, September 2006 , pp. 1025-1032(8)

Publisher: Bentham Science Publishers

The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi

Authors: dos Reis, Flavia C. G.; Júdice, Wagner A. S.; Juliano, Maria A.; Juliano, Luiz; Scharfstein, Julio; de A. Lima, Ana Paula C.

Source: FEMS Microbiology Letters, Volume 259, Number 2, June 2006 , pp. 215-220(6)

Publisher: Blackwell Publishing

Inhibitors of Cysteine Proteases

Authors: Vicik, Radim; Busemann, Matthias; Baumann, Knut; Schirmeister, Tanja

Source: Current Topics in Medicinal Chemistry, Volume 6, Number 4, February 2006 , pp. 331-353(23)

Publisher: Bentham Science Publishers

Carboxydipeptidase activities of recombinant cysteine peptidases

Authors: Judice, Wagner A. S.; Puzer, Luciano; Cotrin, Simone S.; Carmona, Adriana K.; Coombs, Graham H.; Juliano, Luiz; Juliano, Maria A.

Source: FEBS Journal, Volume 271, Number 5, March 2004 , pp. 1046-1053(8)

Publisher: Blackwell Publishing

The Synthesis of Parasitic Cysteine Protease and Trypanothione Reductase Inhibitors

Authors: Chibale Kelly; Musonda Chitalu C.

Source: Current Medicinal Chemistry, Volume 10, Number 18, September 2003 , pp. 1863-1889(27)

Publisher: Bentham Science Publishers

Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

Authors: Huang L.; Brinen L.S.; Ellman J.A.

Source: Bioorganic and Medicinal Chemistry, Volume 11, Number 1, 2 January 2003 , pp. 21-29(9)

Publisher: Elsevier

General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain

Authors: Huang L.; Ellman J.A.

Source: Bioorganic and Medicinal Chemistry Letters, Volume 12, Number 20, 21 October 2002 , pp. 2993-2996(4)

Publisher: Elsevier

CoMFA and HQSAR of acylhydrazide cruzain inhibitors

Authors: Rodrigues C.R.; Flaherty T.M.; Springer C.; McKerrow J.H.; Cohen F.E.

Source: Bioorganic and Medicinal Chemistry Letters, Volume 12, Number 11, 3 June 2002 , pp. 1537-1541(5)

Publisher: Elsevier

Thiol-Dependent Enzymes and Their Inhibitors: A Review

Authors: Leung-Toung R.; Li W.; Tam T.F.; Kaarimian K.

Source: Current Medicinal Chemistry, Volume 9, Number 9, May 2002 , pp. 979-1002(24)

Publisher: Bentham Science Publishers

Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries

Authors: Mathieu M.A.; Bogyo M.; Caffrey C.R.; Choe Y.; Lee J.; Chapman H.; Sajid M.; Craik C.S.; McKerrow J.H.

Source: Molecular and Biochemical Parasitology, Volume 121, Number 1, 30 April 2002 , pp. 99-105(7)

Publisher: Elsevier

S₁ subsite specificity of a recombinant cysteine proteinase, CPB, of Leishmania mexicana compared with cruzain, human cathepsin L and papain using substrates containing non-natural basic amino acids

Authors: Alves, Lira C.; Melo, Robson L.; Sanderson, Sanya J.; Mottram, Jeremy C.; Coombs, Graham H.; Caliendo, Giuseppe; Santagada, Vincenzo; Juliano, Luiz; Juliano, Maria A.

Source: FEBS Journal, Volume 268, Number 5, March 2001 , pp. 1206-1212(7)

Publisher: Blackwell Publishing

Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi

Authors: Judice, Wagner A. S.; Cezari, Maria Helena S.; Lima, Ana Paula C. A.; Scharfstein, Julio; Chagas, Jair Ribeiro; Tersariol, Ivarne L. S.; Juliano, Maria A.; Juliano, Luiz

Source: FEBS Journal, Volume 268, Number 24, December 2001 , pp. 6578-6586(9)

Publisher: Blackwell Publishing

Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides

Authors: Lecaille^a1 F.; Cotton^b J.; McKerrow^c J.H.; Ferrer-Di Martino^a M.; Boll-Bataille^a E.; Gauthier^a F.; Lalmanach^a G.

Source: FEBS Letters, Volume 507, Number 3, 2 November 2001 , pp. 362-366(5)

Publisher: Elsevier

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense

Authors: Caffrey C.R.; Hansell E.; Lucas K.D.; Brinen L.S.; Alvarez Hernandez A.; Cheng J.; Gwaltney S.L.; Roush W.R.; Stierhof Y.-D.; Bogyo M.; Steverding D.; McKerrow J.H.

Source: Molecular and Biochemical Parasitology, Volume 118, Number 1, November 2001 , pp. 61-73(13)

Publisher: Elsevier

Analysis of the S₂ subsite specificities of the recombinant cysteine proteinases CPB of Leishmania mexicana, and cruzain of Trypanosoma cruzi, using fluorescent substrates containing non-natural basic amino acids

Authors: Alves L.C.; Melo R.L.; Cezari M.H.S.; Sanderson S.J.; Mottram J.C.; Coombs G.H.; Juliano L.; Juliano M.A.

Source: Molecular and Biochemical Parasitology, Volume 117, Number 2, 1 October 2001 , pp. 137-143(7)

Publisher: Elsevier

Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain

Authors: Roush W.R.; Cheng J.; Knapp-Reed B.; Alvarez-Hernandez A.; McKerrow J.H.; Hansell E.; Engel J.C.

Source: Bioorganic and Medicinal Chemistry Letters, Volume 11, Number 20, 22 October 2001 , pp. 2759-2762(4)

Publisher: Elsevier