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New Bisquaternary Isoquinolinium Inhibitors of Brain Cholinesterases - Synthesis and Anticholinesterase Activity

Authors: Binder, Jiri; Paar, Martin; Jun, Daniel; Pohanka, Miroslav; Hrabinova, Martina; Opletalova, Veronika; Kuca, Kamil

Source: Letters in Drug Design & Discovery, Volume 7, Number 1, January 2010 , pp. 1-4(4)

Publisher: Bentham Science Publishers

Rivastigmine Transdermal Patch Skin Tolerability: Results of a 1-Year Clinical Trial in Patients with Mild-to-Moderate Alzheimer's Disease

Authors: Cummings, Jeffrey L.; Farlow, Martin R.; Meng, Xiangyi; Tekin, Sibel; Olin, Jason T.

Source: Clinical Drug Investigation, Volume 30, Number 1, 1 January 2010 , pp. 41-49(9)

Publisher: Adis International

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

Authors: Correia, Sónia C.; Moreira, Paula I.

Source: Journal of Neurochemistry, Volume 112, Number 1, January 2010 , pp. 1-12(12)

Publisher: Blackwell Publishing

Alzheimer's β-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2

Authors: Patel, Nikunj S.; Mathura, Venkatarajan S.; Bachmeier, Corbin; Beaulieu-Abdelahad, David; Laporte, Vincent; Weeks, Ophelia; Mullan, Michael; Paris, Daniel

Source: Journal of Neurochemistry, Volume 112, Number 1, January 2010 , pp. 66-76(11)

Publisher: Blackwell Publishing

Safety and tolerability of rivastigmine transdermal patch compared with rivastigmine capsules in patients switched from donepezil: data from three clinical trials

Authors: Sadowsky, C. H.; Farlow, M. R.; Meng, X.; Olin, J. T.

Source: International Journal of Clinical Practice, Volume 64, Number 2, January 2010 , pp. 188-193(6)

Publisher: Blackwell Publishing

Start Small and Stay Small: Minimizing Attrition in the Clinic with a Focus on CNS Therapeutics

Author: Nienaber, Vicki

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 18, December 2009 , pp. 1688-1704(17)

Publisher: Bentham Science Publishers

Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease

Authors: Huang, Austin; Stultz, Collin M

Source: Future Medicinal Chemistry, Volume 1, Number 3, June 2009 , pp. 467-482(16)

Publisher: Future Science

Non-Atheroprotective Effects of Statins: A Systematic Review

Authors: Beri, Abhimanyu; Sural, Neethi; Mahajan, Snigdha B.

Source: American Journal of Cardiovascular Drugs, Volume 9, Number 6, 1 December 2009 , pp. 361-370(10)

Publisher: Adis International

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease

Authors: Martins, Ian J.; Berger, Tamar; Sharman, Matthew J.; Verdile, Giuseppe; Fuller, Stephanie J.; Martins, Ralph N.

Source: Journal of Neurochemistry, Volume 111, Number 6, December 2009 , pp. 1275-1308(34)

Publisher: Blackwell Publishing

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

Authors: Jäger, Sebastian; Leuchtenberger, Stefanie; Martin, Anne; Czirr, Eva; Wesselowski, Johanna; Dieckmann, Marco; Waldron, Elaine; Korth, Carsten; Koo, Edward H.; Heneka, Michael; Weggen, Sascha; Pietrzik, Claus U.

Source: Journal of Neurochemistry, Volume 111, Number 6, December 2009 , pp. 1369-1382(14)

Publisher: Blackwell Publishing

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9

Authors: Koronyo-Hamaoui, Maya; Ko, MinHee K.; Koronyo, Yosef; Azoulay, David; Seksenyan, Akop; Kunis, Gilad; Pham, Michael; Bakhsheshian, Joshua; Rogeri, Patricia; Black, Keith L.; Farkas, Daniel L.; Schwartz, Michal

Source: Journal of Neurochemistry, Volume 111, Number 6, December 2009 , pp. 1409-1424(16)

Publisher: Blackwell Publishing

Amyloid β serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration

Authors: Arevalo, Maria-Ángeles; Roldan, Pedro M.; Chacón, Pedro J.; Rodríguez-Tebar, Alfredo

Source: Journal of Neurochemistry, Volume 111, Number 6, December 2009 , pp. 1425-1433(9)

Publisher: Blackwell Publishing

Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery

Authors: Cousins, Sarah L.; Hoey, Sarah E. A.; Anne Stephenson, F.; Perkinton, Michael S.

Source: Journal of Neurochemistry, Volume 111, Number 6, December 2009 , pp. 1501-1513(13)

Publisher: Blackwell Publishing

Granulocyte-macrophage colony-stimulating factor antibody suppresses microglial activity: implications for anti-inflammatory effects in Alzheimer's Disease and multiple sclerosis

Authors: Hemachandra Reddy, P.; Manczak, Maria; Zhao, Wei; Nakamura, Kazuhiro; Bebbington, Christopher; Yarranton, Geoffrey; Mao, Peizhong

Source: Journal of Neurochemistry, Volume 111, Number 6, December 2009 , pp. 1514-1528(15)

Publisher: Blackwell Publishing

D-Hormone Derivatives for the Treatment of Osteoporosis: From Alfacalcidol to Eldecalcitol

Author: Kubodera, Noboru

Source: Mini Reviews in Medicinal Chemistry, Volume 9, Number 12, October 2009 , pp. 1416-1422(7)

Publisher: Bentham Science Publishers

Computational insights into the development of novel therapeutic strategies for Alzheimer's disease

Author: Prabhakar, Rajeev

Source: Future Medicinal Chemistry, Volume 1, Number 1, April 2009 , pp. 119-135(17)

Publisher: Future Science

Role of Infection in the Pathogenesis of Alzheimer's Disease: Implications for Treatment

Authors: Holmes, Clive; Cotterell, Darren

Source: CNS Drugs, Volume 23, Number 12, 1 December 2009 , pp. 993-1002(10)

Publisher: Adis International

The structure and function of Alzheimer's gamma secretase enzyme complex

Authors: Krishnaswamy, Sudarsan; Verdile, Giuseppe; Groth, David; Kanyenda, Limbikani; Martins, Ralph N

Source: Critical Reviews in Clinical Laboratory Sciences, Volume 46, Numbers 5-6, December 2009 , pp. 282-301(20)

Publisher: Informa Healthcare

Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease

Authors: Roher, Alex E.; Maarouf, Chera L.; Sue, Lucia I.; Hu, Yiran; Wilson, Jeffrey; Beach, Thomas G.

Source: Biomarkers, Volume 14, Number 7, November 2009 , pp. 493-501(9)

Publisher: Informa Healthcare

Involvement of paraoxonase 1 genetic variants in Alzheimer's disease neuropathology

Authors: Leduc, Valérie; Théroux, Louise; Dea, Doris; Robitaille, Yves; Poirier, Judes

Source: European Journal of Neuroscience, Volume 30, Number 9, November 2009 , pp. 1823-1830(8)

Publisher: Blackwell Publishing