Search Results

Recent Patents on Positive Allosteric Modulators of the Metabotropic Glutamate 5 Receptor as a Potential Treatment for Schizophrenia

Authors: Kanuma, Kosuke; Aoki, Takeshi; Shimazaki, Youichi

Source: Recent Patents on CNS Drug Discovery, Volume 5, Number 1, January 2010 , pp. 23-34(12)

Publisher: Bentham Science Publishers

Molecular Recognition and Drug-Lead Identification: What Can Molecular Simulations Tell Us?

Authors: Morra, G.; Genoni, A.; Neves, M. A.C.; Merz Jr., K. M.; Colombo, G.

Source: Current Medicinal Chemistry, Volume 17, Number 1, January 2010 , pp. 25-41(17)

Publisher: Bentham Science Publishers

Allosteric networks governing regulation and catalysis of Src-family protein tyrosine kinases: Implications for disease-associated kinases

Authors: Cheng, Heung-Chin; Johnson, Timothy M; Mills, Ryan D; Chong, Yuh-Ping; Chan, Khai-Chew; Culvenor, Janetta G

Source: Clinical and Experimental Pharmacology and Physiology, Volume 37, Number 1, January 2010 , pp. 93-101(9)

Publisher: Blackwell Publishing

Cognitive Improvement by Activation of α7 Nicotinic Acetylcholine Receptors: From Animal Models to Human Pathophysiology

Authors: Thomsen, Morten S.; Hansen, Henrik H.; Timmerman, Mikkelsen B.; Mikkelsen, Jens D.

Source: Current Pharmaceutical Design, Volume 16, Number 3, January 2010 , pp. 323-343(21)

Publisher: Bentham Science Publishers

Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges

Authors: Li, Hui; Shi, Stephanie T

Source: Future Medicinal Chemistry, Volume 2, Number 1, January 2010 , pp. 121-141(21)

Publisher: Future Science

Positive allosteric modulation of α7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons

Authors: Hu, Min; Gopalakrishnan, Murali; Li, Jinhe

Source: British Journal of Pharmacology, Volume 158, Number 8, December 2009 , pp. 1857-1864(8)

Publisher: Blackwell Publishing

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease

Authors: Hopkins, Corey R; Lindsley, Craig W; Niswender, Colleen M

Source: Future Medicinal Chemistry, Volume 1, Number 3, June 2009 , pp. 501-513(13)

Publisher: Future Science

Emerging cognitive enhancing drugs

Author: Buccafusco, Jerry J

Source: Expert Opinion on Emerging Drugs, Volume 14, Number 4, December 2009 , pp. 577-589(13)

Publisher: Informa Healthcare

How Important are S100A8/S100A9 Calcium Binding Proteins for the Activation of Phagocyte NADPH Oxidase, Nox2

Authors: Berthier, Sylvie; Baillet, Athan; Paclet, Marie-Helene; Gaudin, Philippe; Morel, Francoise

Source: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Cu, Volume 8, Number 4, December 2009 , pp. 282-289(8)

Publisher: Bentham Science Publishers

Use of engineered Escherichia coli cells to detect estrogenicity in everyday consumer products

Authors: Gawrys, Michelle D.; Hartman, Izabela; Landweber, Laura F.; Wood, David W.

Source: Journal of Chemical Technology & Biotechnology, Volume 84, Number 12, December 2009 , pp. 1834-1840(7)

Publisher: John Wiley & Sons, Ltd.

Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design

Authors: Verkhivker, Gennady M.; Dixit, Anshuman; Morra, Giulia; Colombo, Giorgio

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 15, November 2009 , pp. 1369-1385(17)

Publisher: Bentham Science Publishers

Determinants for the cAMP-binding site at the S-adenosylhomocysteine-hydrolase

Authors: Kloor, Doris; Hermes, Marina; Kirschler, Julia; Müller, Margret; Hagen, Norbert; Kalbacher, Hubert; Stevanovic, Stefan; Osswald, Hartmut

Source: Naunyn-Schmiedeberg's Archives of Pharmacology, Volume 380, Number 3, September 2009 , pp. 215-222(8)

Publisher: Springer

Functional and small-angle X-ray scattering studies of a new stationary phase survival protein E (SurE) from Xylella fastidiosa- evidence of allosteric behaviour

Authors: Saraiva, Antonio M.; Reis, Marcelo A.; Tada, Susely F.; Rosselli-Murai, Luciana K.; Schneider, Dilaine R. S.; Pelloso, Alexandre C.; Toledo, Marcelo A. S.; Giles, Carlos; Aparicio, Ricardo; de Souza, Anete P.

Source: FEBS Journal, Volume 276, Number 22, November 2009 , pp. 6751-6762(12)

Publisher: Blackwell Publishing

Analysis of c-Met Kinase Domain Complexes: A New Specific Catalytic Site Receptor Model for Defining Binding Modes of ATP-Competitive Ligands

Authors: Asses, Yasmine; Leroux, Vincent; Tairi-Kellou, Safia; Dono, Rosanna; Maina, Flavio; Maigret, Bernard

Source: Chemical Biology & Drug Design, Volume 74, Number 6, December 2009 , pp. 560-570(11)

Publisher: Blackwell Publishing

Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors

Authors: Briggs, Clark A; Grønlien, Jens Halvard; Curzon, Peter; Timmermann, Daniel B; Ween, Hilde; Thorin-Hagene, Kirsten; Kerr, Paige; Anderson, David J; Malysz, John; Dyhring, Tino; Olsen, Gunnar M; Peters, Dan; Bunnelle, William H; Gopalakrishnan, Murali

Source: British Journal of Pharmacology, Volume 158, Number 6, November 2009 , pp. 1486-1494(9)

Publisher: Blackwell Publishing

Recent Progress in the Development of mGluR4 Positive Allosteric Modulators for the Treatment of Parkinson's Disease

Authors: Lindsley, Craig W.; Niswender, Colleen M.; Engers, Darren W.; Hopkins, Corey R.

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 10, July 2009 , pp. 949-963(15)

Publisher: Bentham Science Publishers

Cinacalcet in Hyperfunctioning Parathyroid Diseases

Authors: Imanishi, Yasuo; Inaba, Masaaki; Kawata, Takehisa; Nishizawa, Yoshiki

Source: Therapeutic Apheresis and Dialysis, Volume 13, Supplement 1, October 2009 , pp. S7-S11(1)

Publisher: Blackwell Publishing

Reduction of Alcohol's Reinforcing and Motivational Properties by the Positive Allosteric Modulator of the GABA_B Receptor, BHF177, in Alcohol-Preferring Rats

Authors: Maccioni, Paola; Carai, Mauro A.M.; Kaupmann, Klemens; Guery, Sébastien; Froestl, Wolfgang; Leite-Morris, Kimberly A.; Gessa, Gian Luigi; Colombo, Giancarlo

Source: Alcoholism Clinical and Experimental Research, Volume 33, Number 10, October 2009 , pp. 1749-1756(8)

Publisher: Blackwell Publishing

Dual effects of aliphatic carboxylic acids on cresolase and catecholase reactions of mushroom tyrosinase

Authors: Gheibi, N.; Saboury, A.A.; Haghbeen, K.; Rajaei, F.; Pahlevan, A.A.

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Number 5, October 2009 , pp. 1076-1081(6)

Publisher: Informa Healthcare

Hemoglobin Conjugated with a Band 3 N-terminus Derived Peptide as an Oxygen Carrier

Authors: Lin, Yen-Lin; Huang, Kuang-Tse

Source: Artificial Cells, Blood Substitutes, and Biotechnology (formerly known as Artif, Volume 37, Number 1, January 2009 , pp. 32-40(9)

Publisher: Taylor and Francis Ltd