Search Results

Structure-based Drug Metabolism Predictions for Drug Design

Authors: Sun, Hao; Scott, Dennis O.

Source: Chemical Biology & Drug Design, Volume 75, Number 1, January 2010 , pp. 3-17(15)

Publisher: Blackwell Publishing

Dipeptide-derived nitriles containing additional electrophilic sites: Potentially irreversible inhibitors of cysteine proteases

Authors: Löser, Reik; Gütschow, Michael

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Number 6, December 2009 , pp. 1245-1252(8)

Publisher: Informa Healthcare

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Authors: Nishiya, Y.; Hagihara, K.; Kurihara, A.; Okudaira, N.; Farid, N.A.; Okazaki, O.; Ikeda, T.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 836-843(8)

Publisher: Informa Healthcare

Active Site Ring-Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases

Authors: Forbes, Christopher; Shi, Qicun; Fisher, Jed F.; Lee, Mijoon; Hesek, Dusan; Llarrull, Leticia I.; Toth, Marta; Gossing, Michael; Fridman, Rafael; Mobashery, Shahriar

Source: Chemical Biology & Drug Design, Volume 74, Number 6, December 2009 , pp. 527-534(8)

Publisher: Blackwell Publishing

Synthetic and Natural Compounds that Interact with Human Cytochrome P450 1A2 and Implications in Drug Development

Authors: Wang, B.; Zhou, S.-F.

Source: Current Medicinal Chemistry, Volume 16, Number 31, November 2009 , pp. 4066-4218(153)

Publisher: Bentham Science Publishers

Metabolic interactions between prokinetic agents domperidone and erythromycin: an in vitro analysis

Authors: Ung, D.; Parkman, H. P.; Nagar, S.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 749-756(8)

Publisher: Informa Healthcare

HDAC inhibitor-based therapies and haematological malignancy

Authors: Stimson, L.; Wood, V.; Khan, O.; Fotheringham, S.; La Thangue, N. B.

Source: Annals of Oncology, Volume 20, Number 8, 22 August 2009 , pp. 1293-1302(10)

Publisher: Oxford University Press

Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development

Authors: Mori, K.; Hashimoto, H.; Takatsu, H.; Tsuda-Tsukimoto, M.; Kume, T.

Source: Xenobiotica, Volume 39, Number 6, June 2009 , pp. 415-422(8)

Publisher: Informa Healthcare

Biological activities of steroidal alkaloids isolated from Solanum leucocarpum

Authors: Nino, J.; Correa, Y. M.; Mosquera, O. M.

Source: Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Volume 47, Number 3, March 2009 , pp. 255-259(5)

Publisher: Informa Healthcare

Mechanism-based inhibition of CYP1A2 by antofloxacin, an 8-NH2 derivative of levofloxacin in rats

Authors: Zhu, Q.; Liao, J.; Xie, L.; Wang, G. J.; Liu, X. D.

Source: Xenobiotica, Volume 39, Number 4, April 2009 , pp. 293-301(9)

Publisher: Informa Healthcare

Rational Design of Multitargeted Tyrosine Kinase Inhibitors: A Novel Approach

Authors: Barchéchath, Sylvie; Williams, Christopher; Saade, Khalil; Lauwagie, Sylvia; Jean-Claude, Bertrand

Source: Chemical Biology & Drug Design, Volume 73, Number 4, April 2009 , pp. 380-387(8)

Publisher: Blackwell Publishing

In Vitro Metabolism Studies of New Adenosine A

Authors: Marucci, Gabriella; Finaurini, Sara; Buccioni, Michela; Lammi, Carmen; Kandhavelu, Meenakshisundaram; Volpini, Rosaria; Ricciutelli, Massimo; Angeli, Piero; Commandeur, Jan N.M.; Cristalli, Gloria

Source: Drug Metabolism Letters, Volume 2, Number 4, December 2008 , pp. 301-307(7)

Publisher: Bentham Science Publishers

In Vitro Cytochrome P450 Inhibition and Induction

Authors: Walsky, Robert L.; Boldt, Sherri E.

Source: Current Drug Metabolism, Volume 9, Number 9, November 2008 , pp. 928-939(12)

Publisher: Bentham Science Publishers

Bayesian Calibration of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model of Carbaryl Cholinesterase Inhibition

Authors: Nong, Andy; Tan, Yu-Mei; Krolski, Michael; Wang, Jiansuo; Lunchick, Curt; Conolly, Rory; Clewell, Harvey

Source: Journal of Toxicology and Environmental Health Part A, Volume 71, Number 20, January 2008 , pp. 1363-1381(19)

Publisher: Taylor and Francis Ltd

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

Authors: Yang, Jiansong; Liao, Mingxiang; Shou, Magang; Jamei, Masoud; Yeo, Karen R.; Tucker, Geoffrey T.; Rostami-Hodjegan, Amin

Source: Current Drug Metabolism, Volume 9, Number 5, June 2008 , pp. 384-393(10)

Publisher: Bentham Science Publishers

Review Article: Cytochrome P450 enzyme, and transport protein mediated herb-drug interactions in renal transplant patients: Grapefruit juice, St John's Wort - and beyond! (Review Article)

Author: NOWACK, RAINER

Source: Nephrology, Volume 13, Number 4, June 2008 , pp. 337-347(11)

Publisher: Blackwell Publishing

Histone Deacetylase Inhibitors: Therapeutic Agents and Research Tools for Deciphering Motor Neuron Diseases

Authors: Echaniz-Laguna, A.; Bousiges, O.; Loeffler, J.-P.; Boutillier, A.-L.

Source: Current Medicinal Chemistry, Volume 15, Number 13, June 2008 , pp. 1263-1273(11)

Publisher: Bentham Science Publishers

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

Author: Zhou, Shu-Feng

Source: Current Drug Metabolism, Volume 9, Number 4, May 2008 , pp. 310-322(13)

Publisher: Bentham Science Publishers

Celecoxib is a CYP1A2 inhibitor in vitro but not in vivo

Authors: Karjalainen, Marjo; Neuvonen, Pertti; Backman, Janne

Source: European Journal of Clinical Pharmacology, Volume 64, Number 5, May 2008 , pp. 511-519(9)

Publisher: Springer

Potential Strategies for Minimizing Mechanism-Based Inhibition of Cytochrome P450 3A4

Author: Zhou, Shu-Feng

Source: Current Pharmaceutical Design, Volume 14, Number 10, April 2008 , pp. 990-1000(11)

Publisher: Bentham Science Publishers