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Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol-adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

Authors: Bérubé, Marie; Poirier, Donald

Source: Canadian Journal of Chemistry, Volume 87, Number 8, 1 August 2009 , pp. 1180-1199(20)

Publisher: NRC Research Press

Editorial [Hot Topic: Protein Targets in the Treatment of Cancers (Guest Editor: Sabbir Ahmed)]

Author: Ahmed, Sabbir

Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry, Volume 9, Number 6, July 2009 , pp. 598-598(1)

Publisher: Bentham Science Publishers

Advances in Development of Inhibitors of 17β-Hydroxysteroid Dehydrogenases

Author: Poirier, Donald

Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry, Volume 9, Number 6, July 2009 , pp. 642-660(19)

Publisher: Bentham Science Publishers

Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1

Authors: Bérubé, Marie; Poirier, Donald

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Number 3, June 2009 , pp. 832-843(12)

Publisher: Informa Healthcare

Antidiabetic effects of 11β-HSD1 inhibition in a mouse model of combined diabetes, dyslipidaemia and atherosclerosis

Authors: Lloyd; Helmering; Cordover; Bowsman; Chen; Hale; Fordstrom; Zhou; Wang; Kaufman; Véniant

Source: Diabetes, Obesity and Metabolism, Volume 11, Number 7, July 2009 , pp. 688-699(12)

Publisher: Blackwell Publishing

Structure and Inhibitor Binding Mechanisms of 11β -Hydroxysteroid Dehydrogenase Type 1

Authors: Wang, Zhulun; Wang, Minghan

Source: Current Chemical Biology, Volume 3, Number 2, May 2009 , pp. 159-170(12)

Publisher: Bentham Science Publishers

Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease

Authors: Hadoke, Patrick W.F.; Iqbal, Javaid; Walker, Brian R.

Source: British Journal of Pharmacology, Volume 156, Number 5, March 2009 , pp. 689-712(24)

Publisher: Blackwell Publishing

Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?

Authors: van Raalte, D. H.; Ouwens, D. M.; Diamant, M.

Source: European Journal of Clinical Investigation, Volume 39, Number 2, February 2009 , pp. 81-93(13)

Publisher: Blackwell Publishing

Steroid Biosynthesis Inhibitors in the Therapy of Hypercortisolism: Theory and Practice

Authors: Igaz, P.; Tombol, Z.; Szabo, P. M.; Liko, I.; Racz, K.

Source: Current Medicinal Chemistry, Volume 15, Number 26, November 2008 , pp. 2734-2747(14)

Publisher: Bentham Science Publishers

Inhibitors of 11β-HSD1: A Potential Treatment for the Metabolic Syndrome

Authors: Jean Jr., David J. S.t.; Wang, Minghan; Fotsch, Christopher

Source: Current Topics in Medicinal Chemistry, Volume 8, Number 17, November 2008 , pp. 1508-1523(16)

Publisher: Bentham Science Publishers

Development of a High-Throughput Cell-Based Assay for 11β-Hydroxysteroid Dehydrogenase Type 1 Using BacMam Technology

Authors: Wang, Da-Yuan; Lu, Quinn; Walsh, Stacey; Payne, Lisa; Modha, Sundip; Scott, Martin; Sweitzer, Thomas; Ames, Robert; Krosky, Daniel; Li, Hu

Source: Molecular Biotechnology, Volume 39, Number 2, June 2008 , pp. 127-134(8)

Publisher: Humana Press

Development of 11β -HSD1 Inhibitors for the Treatment of Type 2 Diabetes

Authors: Hale, Clarence; Wang, Minghan

Source: Mini Reviews in Medicinal Chemistry, Volume 8, Number 7, June 2008 , pp. 702-710(9)

Publisher: Bentham Science Publishers

Induction of hepatic 11β-hydroxysteroid dehydrogenase type 1 in patients with alcoholic liver disease

Authors: Ahmed, Adeeba; Saksena, Sushma; Sherlock, Mark; Olliff, Simon P.; Elias, Elwyn; Stewart, Paul M.

Source: Clinical Endocrinology, Volume 68, Number 6, June 2008 , pp. 898-903(6)

Publisher: Blackwell Publishing

11-Beta-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors in Type 2 diabetes mellitus and obesity

Authors: Hughes, Katherine A; Webster, Scott P; Walker, Brian R

Source: Expert Opinion on Investigational Drugs, Volume 17, Number 4, April 2008 , pp. 481-496(16)

Publisher: Informa Healthcare

The Role of 11Beta-Hydroxysteroid Dehydrogenase in Metabolic Disease and Therapeutic Potential of 11Beta-HSD1 Inhibitors

Author: Saiah, Eddine

Source: Current Medicinal Chemistry, Volume 15, Number 7, March 2008 , pp. 642-649(8)

Publisher: Bentham Science Publishers

Ligand supplementation as a method to increase soluble heterologous protein production

Authors: Hozjan, Viktorija; Guo, Kunde; Wu, Xiaoqiu; Oppermann, Udo

Source: Expert Review of Proteomics, Volume 5, Number 1, February 2008 , pp. 137-143(7)

Publisher: Expert Reviews

Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

Authors: Gobec, S.; Brozic, P.; Rizner, T. L.

Source: Current Medicinal Chemistry, Volume 15, Number 2, January 2008 , pp. 137-150(14)

Publisher: Bentham Science Publishers

Inhibition of 17β -Hydroxysteroid Dehydrogenase (17β -HSD) by Imidazole-Based Compounds

Authors: Ahmed, Sabbir; Olusanjo, Moniola S.; Shahid, Imran; Owen, Caroline P.

Source: Letters in Drug Design & Discovery, Volume 5, Number 1, January 2008 , pp. 48-51(4)

Publisher: Bentham Science Publishers

New inhibitors of fungal 17β-hydroxysteroid dehydrogenase based on the [1,5]-benzodiazepine scaffold

Authors: Zivec, Matej; Sova, Matej; Brunskole, Mojca; Lenarsic, Roman; Rizner, Tea Lanisnik; Gobec, Stanislav

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 22, Number 1, February 2007 , pp. 29-36(8)

Publisher: Informa Healthcare

Inhibitory effects of diesel exhaust components and flavonoids on 20α-hydroxysteroid dehydrogenase activity in mouse tissues

Authors: Shimada, Hideaki; Ohtaguro, Misa; Miura, Kazumi; Imamura, Yorishige

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 22, Number 4, August 2007 , pp. 445-449(5)

Publisher: Informa Healthcare