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Recent Advances in the Impurity Profiling of Drugs

Authors: Bartos, Dorottya; Gorog, Sandor

Source: Current Pharmaceutical Analysis, Volume 4, Number 4, November 2008 , pp. 215-230(16)

Publisher: Bentham Science Publishers

Metabolism of 3-chloro-4-fluoroaniline in rat using [ 14 C]-radiolabelling, 19 F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR

Authors: Duckett, C. J.; Lindon, J. C.; Walker4, H.; Abou-Shakra5, F.; Wilson, I. D.; Nicholson, J. K.

Source: Xenobiotica, Volume 36, Number 1, Number 1/January 2006 , pp. 59-77(19)

Publisher: Informa Healthcare

Characterization of the metabolites of alosetron in experimental animals and human

Authors: Ismail, I. M; Andrew, P. D; Cholerton, J; Roberts, A. D; Dear, G. J; Taylor, S; Koch, K. M; Saynor, D. A

Source: Xenobiotica, Volume 35, Number 2, February 2005 , pp. 131-154(24)

Publisher: Informa Healthcare

HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong

Authors: Zschocke S.; Klaiber I.; Bauer R.; Vogler B.

Source: Molecular Diversity, Volume 9, Numbers 1-3, January 2005 , pp. 33-39(7)

Publisher: Springer

Characterization and quantification of metabolites of racemic ketoprofen excreted in urine following oral administration to man by 1 H-NMR spectroscopy, directly coupled HPLC-MS and HPLC-NMR, and circular dichroism

Authors: E. Skordi; I. D. Wilson; J. C. Lindon; J. K. Nicholson

Source: Xenobiotica, Volume 34, Numbers 11-12, Numbers 11-12/November/December 2004 , pp. 1075-1089(15)

Publisher: Informa Healthcare

Testosterone 1β-hydroxylation by human cytochrome P450 3A4

Authors: Krauser, Joel A.; Voehler, Markus; Tseng, Li-Hong; Schefer, Alexandre B.; Godejohann, Markus; Guengerich, F. Peter

Source: FEBS Journal, Volume 271, Number 19, October 2004 , pp. 3962-3969(8)

Publisher: Blackwell Publishing

High-performance liquid chromatographic-nuclear magnetic resonance investigation of the isomerization of alachlor-ethanesulfonic acid

Authors: Cardoza L.A.; Cutak B.J.; Ketter J.; Larive C.K.

Source: Journal of Chromatography A, Volume 1022, Number 1, 2 January 2004 , pp. 131-137(7)

Publisher: Elsevier

Separations coupled with NMR detection

Authors: Cardoza L.A.; Almeida V.K.; Carr A.; Larive C.K.; Graham D.W.

Source: TrAC Trends in Analytical Chemistry, Volume 22, Number 10, November 2003 , pp. 766-775(10)

Publisher: Elsevier

One-dimensional ¹³C NMR and HPLC-¹H NMR techniques for observing carbon-13 and deuterium labelling in biosynthetic studies

Authors: Schneider B.; Gershenzon J.; Graser G.; Hölscher D.; Schmitt B.

Source: Phytochemistry Reviews, Volume 2, Numbers 1-2, 2003 , pp. 31-43(13)

Publisher: Springer

Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR

Authors: Zhang J-L.; Che Q-M.; Li S-Z.; Zhou T-H.

Source: Journal of Asian Natural Products Research, Volume 5, Number 4, September 2003 , pp. 249-256(8)

Publisher: Taylor and Francis Ltd

Evariquinone, isoemericellin, and stromemycin from a sponge derived strain of the fungus Emericella variecolor

Authors: Bringmann G.; Lang G.; Steffens S.; Gunther E.; Schaumann K.

Source: Phytochemistry, Volume 63, Number 4, June 2003 , pp. 437-443(7)

Publisher: Elsevier

Analysis of a ginger extract by high-performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy using superheated deuterium oxide as the mobile phase

Authors: Saha S.; Smith R.M.; Lenz E.; Wilson I.D.

Source: Journal of Chromatography A, Volume 991, Number 1, 28 March 2003 , pp. 143-150(8)

Publisher: Elsevier

The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy

Authors: Tugnait M.; Lenz E.M.; Hofmann M.; Spraul M.; Wilson I.D.; Lindon J.C.; Nicholson J.K.

Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 30, Number 5, 1 January 2003 , pp. 1561-1574(14)

Publisher: Elsevier

Simultaneous enantioresolution and assignment of absolute configuration of secondary alcohols by directly coupled HPLC-NMR of 9-AMA esters

Authors: Seco J.M.; Tseng L.-H.; Godejohann M.; Quinoa E.; Riguera R.

Source: Tetrahedron: Asymmetry, Volume 13, Number 19, 4 October 2002 , pp. 2149-2153(5)

Publisher: Elsevier

Metabolism of 4-fluoroaniline and 4-fluorobiphenyl in the earthworm Eisenia veneta characterized by high-resolution NMR spectroscopy with directly coupled HPLC-NMR and HPLC-MS

Authors: Bundy J. G.; Lenz E. M.; Osborn D.; Weeks J. M.; Lindon J. C.; Nicholson J. K.

Source: Xenobiotica, Volume 32, Number 6, 1 June 2002 , pp. 479-490(12)

Publisher: Informa Healthcare

Review of the analytical techniques for sesquiterpenes and sesquiterpene lactones

Author: Merfort I.

Source: Journal of Chromatography A, Volume 967, Number 1, 16 August 2002 , pp. 115-130(16)

Publisher: Elsevier

Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide

Authors: Ruhl R.; Thiel R.; Lacker T.S.; Strohschein S.; Albert K.; Nau H.

Source: Journal of Chromatography B: Biomedical Sciences and Applications, Volume 757, Number 1, 5 June 2001 , pp. 101-109(9)

Publisher: Elsevier

Directly Coupled High-Performance Liquid Chromatography and Nuclear Magnetic Resonance Spectroscopic with Chemometric Studies on Metabolic Variation in Sprague–Dawley Rats

Authors: Gavaghan C.L.; Nicholson J.K.; Connor S.C.; Wilson I.D.; Wright B.; Holmes E.

Source: Analytical Biochemistry, Volume 291, Number 2, April 2001 , pp. 245-252(8)

Publisher: Academic Press

Directly coupled HPLC-NMR and HPLC-MS approaches for the rapid characterisation of drug metabolites in urine: application to the human metabolism of naproxen

Authors: Sidelmann U.G.; Bjornsdottir I.; Shockcor J.P.; Hansen S.H.; Lindon J.C.; Nicholson J.K.

Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 24, Number 4, February 2001 , pp. 569-579(11)

Publisher: Elsevier

LC-¹H NMR used for determination of the elution order of S-naproxen glucuronide isomers in two isocratic reversed-phase LC-systems

Authors: Mortensen R.W.; Corcoran O.; Cornett C.; Sidelmann U.G.; Troke J.; Lindon J.C.; Nicholson J.K.; Hansen S.H.

Source: Journal of Pharmaceutical and Biomedical Analysis, Volume 24, Number 3, January 2001 , pp. 477-485(9)

Publisher: Elsevier