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Advances in fragment-based drug discovery platforms

Authors: Orita, Masaya; Warizaya, Masaichi; Amano, Yasushi; Ohno, Kazuki; Niimi, Tatsuya

Source: Expert Opinion on Drug Discovery, Volume 4, Number 11, November 2009 , pp. 1125-1144(20)

Publisher: Informa Healthcare

Streamlining hit discovery and optimization with a yoctoliter scale DNA reactor

Authors: Heitner, Tara Renee; Hansen, Nils Jakob Vest

Source: Expert Opinion on Drug Discovery, Volume 4, Number 11, November 2009 , pp. 1201-1213(13)

Publisher: Informa Healthcare

Editorial [Hot topic: Exploring Novel Chemical Space Through the Use of Computational and Structural Biology (Guest Editor: Alan C. Rigby)]

Author: Rigby, Alan C.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 12, Number 10, December 2009 , pp. 927-928(2)

Publisher: Bentham Science Publishers

Challenges for Drug Discovery - A Case Study of Urokinase Receptor Inhibition

Authors: Chen, Zhuo; Lin, Lin; Huai, Qing; Huang, Mingdong

Source: Combinatorial Chemistry & High Throughput Screening, Volume 12, Number 10, December 2009 , pp. 961-967(7)

Publisher: Bentham Science Publishers

Protein-Protein Interaction Inhibition (2P2I): Fewer and Fewer Undruggable Targets

Authors: Betzi, Stephane; Guerlesquin, Francoise; Morelli, Xavier

Source: Combinatorial Chemistry & High Throughput Screening, Volume 12, Number 10, December 2009 , pp. 968-983(16)

Publisher: Bentham Science Publishers

G Protein-Coupled Receptors: Target-Based In Silico Screening

Authors: Senderowitz, Hanoch; Marantz, Yael

Source: Current Pharmaceutical Design, Volume 15, Number 35, December 2009 , pp. 4049-4068(20)

Publisher: Bentham Science Publishers

Conference Report: Inaugural Target Discovery World Congress 2009

Author: Chaguturu, Rathnam

Source: Future Medicinal Chemistry, Volume 1, Number 7, October 2009 , pp. 1211-1214(4)

Publisher: Future Science

Protostellar discs formed from rigidly rotating cores

Authors: Walch, S.; Burkert, A.; Whitworth, A.; Naab, T.; Gritschneder, M.

Source: Monthly Notices of the Royal Astronomical Society, Volume 400, Number 1, November 2009 , pp. 13-25(13)

Publisher: Blackwell Publishing

Doppler and modulation tomography of XTE J1118+480 in quiescence

Authors: Calvelo, D. E.; Vrtilek, S. D.; Steeghs, D.; Torres, M. A. P.; Neilsen, J.; Filippenko, A. V.; González Hernández, J. I.

Source: Monthly Notices of the Royal Astronomical Society, Volume 399, Number 2, October 2009 , pp. 539-549(11)

Publisher: Blackwell Publishing

Advertencias explícitas y falsas memorias para un suceso en adultos jóvenes y mayores

Authors: Aizpurua, Alaitz; García-Bajos, Elvirag; Migueles, Malen

Source: Estudios de Psicología, Volume 30, Number 3, November 2009 , pp. 291-302(12)

Publisher: Fundación Infancia y Aprendizaje

Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining

Authors: Thepchatri, Pahk; Min, Jaeki; Ganesh, Thota; Du, Yuhong; Lewis, Iestyn; Kurtkaya, Serdar; Prussia, Andrew; Li, Lian; Sneed, Blossom; Plemper, Richard K.; Fu, Haian; Liotta, Dennis C.; Snyder, James P.; Dingledine, Raymond; Sun, Aiming

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 13, September 2009 , pp. 1159-1171(13)

Publisher: Bentham Science Publishers

A Case Study from the Chemistry Core of the Pittsburgh Molecular Library Screening Center: The Polo-like Kinase Polo-Box Domain (Plk1- PBD)

Authors: Wipf, Peter; Arnold, David; Carter, Karen; Dong, Shuzhi; Johnston, Paul A.; Sharlow, Elizabeth; Lazo, John S.; Huryn, Donna H.

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 13, September 2009 , pp. 1194-1205(12)

Publisher: Bentham Science Publishers

The Identification, Characterization and Optimization of Small Molecule Probes of Cysteine Proteases: Experiences of the Penn Center for Molecular Discovery with Cathepsin B and Cathepsin L

Authors: Huryn, Donna M.; Smith III, Amos B.

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 13, September 2009 , pp. 1206-1216(11)

Publisher: Bentham Science Publishers

Extraction of Structure-Activity Relationship Information from High-Throughput Screening Data

Authors: Wawer, M.; Bajorath, J.

Source: Current Medicinal Chemistry, Volume 16, Number 31, November 2009 , pp. 4049-4057(9)

Publisher: Bentham Science Publishers

Convergence of multiple hits that could underlie Parkinson's disease

Authors: Mosharov, Eugene V; Sulzer, David

Source: Future Neurology, Volume 4, Number 5, September 2009 , pp. 525-529(5)

Publisher: Future Medicine

On the dissolution of star clusters in the Galactic Centre - I. Circular orbits

Authors: Ernst, A.; Just, A.; Spurzem, R.

Source: Monthly Notices of the Royal Astronomical Society, Volume 399, Number 1, October 2009 , pp. 141-156(16)

Publisher: Blackwell Publishing

Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution

Authors: Rha, Eugene; Kim, Sujin; Choi, Su-Lim; Hong, Seung-Pyo; Sung, Moon-Hee; Song, Jae J.; Lee, Seung-Goo

Source: FEBS Journal, Volume 276, Number 21, November 2009 , pp. 6187-6194(8)

Publisher: Blackwell Publishing

Billiards in a General Domain with Random Reflections

Authors: Comets, Francis; Popov, Serguei; Schütz, Gunter; Vachkovskaia, Marina

Source: Archive for Rational Mechanics and Analysis, Volume 191, Number 3, March 2009 , pp. 497-537(41)

Publisher: Springer

Structure-Based Drug Design Strategies in Medicinal Chemistry

Authors: Andricopulo, Adriano D.; Salum, Lívia B.; Abraham, Donald J.

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 9, June 2009 , pp. 771-790(20)

Publisher: Bentham Science Publishers

Structure-Based Drug Discovery for Tropical Diseases

Authors: Guido, Rafael V.C.; Oliva, Glaucius

Source: Current Topics in Medicinal Chemistry, Volume 9, Number 9, June 2009 , pp. 824-843(20)

Publisher: Bentham Science Publishers