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Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole

Authors: Lehr, Thorsten; Staab, Alexander; Trommeshauser, Dirk; >Hans Guenter Schaefer,; Kloft, Charlotte

Source: Clinical Pharmacokinetics, Volume 49, Number 1, 1 January 2010 , pp. 53-66(14)

Publisher: Adis International

Inter-individual difference determinant of prednisolone pharmacokinetics for Japanese renal transplant recipients in the maintenance stage

Authors: Miura, M.; Inoue, K.; Kagaya, H.; Saito, M.; Habuchi, T.; Satoh, S.

Source: Xenobiotica, Volume 39, Number 12, December 2009 , pp. 939-945(7)

Publisher: Informa Healthcare

Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype

Authors: Scholz, Ina; Oberwittler, Heike; Riedel, Klaus-Dieter; Burhenne, Jürgen; Weiss, Johanna; Haefeli, Walter E.; Mikus, Gerd

Source: British Journal of Clinical Pharmacology, Volume 68, Number 6, December 2009 , pp. 906-915(10)

Publisher: Blackwell Publishing

Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo

Authors: Bae, Soo H.; Bae, Soo K.; Lee, Myung G.

Source: Journal of Pharmacy and Pharmacology, Volume 61, Number 12, December 2009 , pp. 1637-1642(6)

Publisher: Pharmaceutical Press

Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers

Authors: Babalola, C. P.; Kolade, Y. T.; Olaniyi, A. A.; Adedapo, A.; Scriba, G. K. E.

Source: Journal of Clinical Pharmacy & Therapeutics, Volume 34, Number 6, December 2009 , pp. 677-682(6)

Publisher: Blackwell Publishing

A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans

Authors: Mukonzo, Jackson K.; Röshammar, Daniel; Waako, Paul; Andersson, Maria; Fukasawa, Takashi; Milani, Lili; Svensson, Jan Olof; Ogwal-Okeng, Jasper; Gustafsson, Lars L.; Aklillu, Eleni

Source: British Journal of Clinical Pharmacology, Volume 68, Number 5, November 2009 , pp. 690-699(10)

Publisher: Blackwell Publishing

Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole

Authors: Grün, Barbara; Krautter, Stefanie; Riedel, Klaus-Dieter; Mikus, Gerd

Source: British Journal of Clinical Pharmacology, Volume 68, Number 5, November 2009 , pp. 712-720(9)

Publisher: Blackwell Publishing

The Role of Human CYP2C8 and CYP2C9 Variants in Pioglitazone Metabolism In Vitro

Authors: Muschler, Eugen; Lal, Jawahar; Jetter, Alexander; Rattay, Anke; Zanger, Ulrich; Zadoyan, Gregor; Fuhr, Uwe; Kirchheiner, Julia

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 6, December 2009 , pp. 374-379(6)

Publisher: Blackwell Publishing

Oxidation of Endobiotics Mediated by Xenobiotic-Metabolizing Forms of Human Cytochrome P450

Authors: Niwa, Toshiro; Murayama, Norie; Yamazaki, Hiroshi

Source: Current Drug Metabolism, Volume 10, Number 7, September 2009 , pp. 700-712(13)

Publisher: Bentham Science Publishers

Insights into the Structure, Function, and Regulation of Human Cytochrome P450 1A2

Authors: Zhou, Shu-Feng; Yang, Li-Ping; Wei, Ming Q.; Duan, Wei; Chan, Eli

Source: Current Drug Metabolism, Volume 10, Number 7, September 2009 , pp. 713-729(17)

Publisher: Bentham Science Publishers

Substrate Specificity, Regulation, and Polymorphism of Human Cytochrome P450 2B6

Authors: Mo, Sui-Lin; Liu, Ya-He; Duan, Wei; Wei, Ming Q.; Kanwar, Jagat R.; Zhou, Shu-Feng

Source: Current Drug Metabolism, Volume 10, Number 7, September 2009 , pp. 730-753(24)

Publisher: Bentham Science Publishers

Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones

Authors: Allmyr, Mats; Panagiotidis, Georgios; Sparve, Erik; Diczfalusy, Ulf; Sandborgh-Englund, Gunilla

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 5, November 2009 , pp. 339-344(6)

Publisher: Blackwell Publishing

In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation

Authors: Chetty, Manoranjenni; d'Esposito, Fabrizio; Zhang, Wei V.; Glen, John; Dore, Glenys; Stankovic, Zvijezdana; Edwards, Robert J.; Ramzan, Iqbal; Murray, Michael

Source: British Journal of Clinical Pharmacology, Volume 68, Number 4, October 2009 , pp. 574-579(6)

Publisher: Blackwell Publishing

Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects

Authors: Nassr, Nassr; Huennemeyer, Andreas; Herzog, Rolf; von Richter, Oliver; Hermann, Robert; Koch, Manuela; Duffy, Kevin; Zech, Karl; Lahu, Gezim

Source: British Journal of Clinical Pharmacology, Volume 68, Number 4, October 2009 , pp. 580-587(8)

Publisher: Blackwell Publishing

New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

Authors: Wang, Bo; Yang, Li-Ping; Zhang, Xiao-Zhuang; Huang, Shui-Qing; Bartlam, Mark; Zhou, Shu-Feng

Source: Drug Metabolism Reviews, Volume 41, Number 4, November 2009 , pp. 573-643(71)

Publisher: Informa Healthcare

Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients

Authors: Elens, Laure; Yombi, Jean-Cyr; Lison, Dominique; Wallemacq, Pierre; Vandercam, Bernard; Haufroid, Vincent

Source: Pharmacogenomics, Volume 10, Number 10, October 2009 , pp. 1589-1597(9)

Publisher: Future Medicine

Delivery of high levels of anti-proliferative nucleoside triphosphates to CYP3A-expressing cells as a potential treatment for hepatocellular carcinoma

Authors: MacKenna, Deidre; Montag, Annika; Boyer, Serge; Linemeyer, David; Erion, Mark

Source: Cancer Chemotherapy and Pharmacology, Volume 64, Number 5, October 2009 , pp. 981-991(11)

Publisher: Springer

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Authors: Murai, K.; Yamazaki, H.; Nakagawa, K.; Kawai, R.; Kamataki, T.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 795-802(8)

Publisher: Informa Healthcare

In vitro model for the prediction of clinical CYP3A4 induction using HepaRG cells

Authors: Kaneko, A.; Kato, M.; Sekiguchi, N.; Mitsui, T.; Takeda, K.; Aso, Y.

Source: Xenobiotica, Volume 39, Number 11, November 2009 , pp. 803-810(8)

Publisher: Informa Healthcare

Is There a Place for Drug Combination Strategies Using Clinical Pharmacology Attributes? - Review of Current Trends in Research

Author: Srinivas, Nuggehally R.

Source: Current Clinical Pharmacology, Volume 4, Number 3, September 2009 , pp. 220-228(9)

Publisher: Bentham Science Publishers