Search Results

CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes

Authors: Cao, Y.-F.; Zhang, Y.-Y.; Li, J.; Ge, G.-B.; Hu, D.; Liu, H.-X.; Huang, T.; Wang, Y.-C.; Fang, Z.-Z.; Sun, D.-X.; Huo, H.; Yin, J.; Yang, L.

Source: Xenobiotica, Volume 40, Number 1, January 2010 , pp. 38-47(10)

Publisher: Informa Healthcare

Pharmacokinetic assessment of a five-probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A

Authors: Turpault, Sandrine; Brian, William; Van Horn, Robert; Santoni, Alix; Poitiers, Franck; Donazzolo, Yves; Boulenc, Xavier

Source: British Journal of Clinical Pharmacology, Volume 68, Number 6, December 2009 , pp. 928-935(8)

Publisher: Blackwell Publishing

Editorial [Special Board Members Issue]

Author: Prakash, Chandra

Source: Current Drug Metabolism, Volume 10, Number 7, September 2009 , pp. 659-660(2)

Publisher: Bentham Science Publishers

Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: Effect of P450 inducers on its toxicity

Authors: Eruvaram, Naveen Reddy; Das, Mukul

Source: Toxicology Mechanisms and Methods, Volume 19, Number 8, October 2009 , pp. 510-517(8)

Publisher: Informa Healthcare

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4′-methanol-bisbenzonitrile in vitro

Authors: Jeong, Seongwook; Woo, Margaret; Flockhart, David; Desta, Zeruesenay

Source: Cancer Chemotherapy and Pharmacology, Volume 64, Number 5, October 2009 , pp. 867-875(9)

Publisher: Springer

Evaluation of Molecular Markers in a Rat Model of Mammary Carcinogenesis

Authors: Vinothini, G.; Murugan, R. Senthil; Nagini, S.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Volume 17, Number 10, 2009 , pp. 483-493(11)

Publisher: Cognizant Communication Corporation

Evaluation of CYP1A1 and CYP2B1/2 m-RNA Induction in Rat Liver Slices Using the NanoString® Technology: A Novel Tool for Drug Discovery Lead Optimization

Authors: Palamanda, Jairam R.; Kumari, Pramila; Murgolo, Nicholas; Benbow, Larry; Lin, Xinjie; Nomeir, Amin A.

Source: Drug Metabolism Letters, Volume 3, Number 3, August 2009 , pp. 171-175(5)

Publisher: Bentham Science Publishers

Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism

Authors: Doki, Kosuke; Homma, Masato; Kuga, Keisuke; Aonuma, Kazutaka; Kohda, Yukinao

Source: British Journal of Clinical Pharmacology, Volume 68, Number 1, July 2009 , pp. 89-96(8)

Publisher: Blackwell Publishing

In vitro metabolism of the specific endothelin-A receptor antagonist ZD4054 and clinical drug interactions between ZD4054 and rifampicin or itraconazole in healthy male volunteers

Authors: Swaisland, H. C.; Oliver, S. D.; Morris, T.; Jones, H. K.; Bakhtyari, A.; Mackey, A.; McCormick, A. D.; Slamon, D.; Hargreaves, J. A.; Millar, A.; Taboada, M. T.

Source: Xenobiotica, Volume 39, Number 6, June 2009 , pp. 444-456(13)

Publisher: Informa Healthcare

Effect of SPG/Indomethacin treatment on sepsis, interleukin-6 production, and expression of hepatic cytochrome P450 isoforms in differing strains of mice

Authors: Saito, Maki; Nameda, Sachiko; Miura, Noriko N.; Adachi, Yoshiyuki; Ohno, Naohito

Source: Journal of Immunotoxicology, Volume 6, Number 1, March 2009 , pp. 42-48(7)

Publisher: Informa Healthcare

In vitro and in vivo assessment of the effect of dalcetrapib on a panel of CYP substrates

Authors: Derks, Michael; Fowler, Stephen; Kuhlmann, Olaf

Source: Current Medical Research and Opinion, Volume 25, Number 4, April 2009 , pp. 891-902(12)

Publisher: Informa Healthcare

Epoxyeicosatrienoic acids: formation, metabolism and potential role in tissue physiology and pathophysiology

Authors: Kaspera, Rüdiger; Totah, Rheem A

Source: Expert Opinion on Drug Metabolism and Toxicology, Volume 5, Number 7, July 2009 , pp. 757-771(15)

Publisher: Informa Healthcare

Inhibitory Properties of Trapping Agents: Glutathione, Potassium Cyanide, and Methoxylamine, Against Major Human Cytochrome P450 Isoforms

Authors: Zhang, Chenghong; Wong, Susan; Delarosa, Erlie M.; Kenny, Jane R.; Halladay, Jason S.; Hop, Cornelis E.; Khojasteh-Bakht, Siamak C.

Source: Drug Metabolism Letters, Volume 3, Number 2, April 2009 , pp. 125-129(5)

Publisher: Bentham Science Publishers

Virtual Screening for Cytochromes P450: Successes of Machine Learning Filters

Authors: Burton, Julien; Ijjaali, Ismail; Petitet, Francois; Michel, Andre; Vercauteren, Daniel P.

Source: Combinatorial Chemistry & High Throughput Screening, Volume 12, Number 4, May 2009 , pp. 369-382(14)

Publisher: Bentham Science Publishers

Characterization of human cytochrome P450 isoforms involved in the metabolism of 7-epi-paclitaxel

Authors: Zhang, Y. -Y.; Liu, Y.; Zhang, J. -W.; Ge, G. -B.; Wang, L. -M.; Sun, J.; Yang, L.

Source: Xenobiotica, Volume 39, Number 4, April 2009 , pp. 283-292(10)

Publisher: Informa Healthcare

Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs

Authors: Hagihara, K.; Kazui, M.; Ikenaga, H.; Nanba, T.; Fusegawa, K.; Takahashi, M.; Kurihara, A.; Okazaki, O.; Farid, N. A.; Ikeda, T.

Source: Xenobiotica, Volume 39, Number 3, March 2009 , pp. 218-226(9)

Publisher: Informa Healthcare

Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment

Authors: Meyer, Ralf Peter; Gehlhaus, Marcel; Schwab, Ricarda; Bürck, Carolin; Knoth, Rolf; Hagemeyer, Christoph Eugen

Source: Journal of Neurochemistry, Volume 109, Number 2, April 2009 , pp. 670-681(12)

Publisher: Blackwell Publishing

Effects of Tributyltin (TBT) on In Vitro Hormonal and Biotransformation Responses in Atlantic Salmon (Salmo salar)

Authors: Mortensen, Anne; Arukwe, Augustine

Source: Journal of Toxicology and Environmental Health Part A, Volume 72, Numbers 3-4, 2009 , pp. 209-218(10)

Publisher: Taylor and Francis Ltd

Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls

Authors: Green, Richard M.; Hodges, Nikolas J.; Chipman, J. Kevin; O'Donovan, Michael R.; Graham, Mark

Source: Mutagenesis, Volume 23, Number 6, 2 November 2008 , pp. 457-463(7)

Publisher: Oxford University Press

The influence of diet composition on phase I and II biotransformation enzyme induction

Authors: Rudolf, Jaime; Bauerly, Kathryn; Tchaparian, Eskouhie; Rucker, Robert; Mitchell, Alyson

Source: Archives of Toxicology, Volume 82, Number 12, December 2008 , pp. 893-901(9)

Publisher: Springer