Search Results

The Role of Human CYP2C8 and CYP2C9 Variants in Pioglitazone Metabolism In Vitro

Authors: Muschler, Eugen; Lal, Jawahar; Jetter, Alexander; Rattay, Anke; Zanger, Ulrich; Zadoyan, Gregor; Fuhr, Uwe; Kirchheiner, Julia

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 6, December 2009 , pp. 374-379(6)

Publisher: Blackwell Publishing

Roles of Different CYP Enzymes in the Formation of Specific Fluvastatin Metabolites by Human Liver Microsomes

Authors: Toda, Takaki; Eliasson, Erik; Ask, Birgitta; Inotsume, Nobuo; Rane, Anders

Source: Basic & Clinical Pharmacology & Toxicology, Volume 105, Number 5, November 2009 , pp. 327-332(6)

Publisher: Blackwell Publishing

Phenotype of hepatic xenobiotic metabolizing enzymes and CYP450 isoforms of sanguinarine treated rats: Effect of P450 inducers on its toxicity

Authors: Eruvaram, Naveen Reddy; Das, Mukul

Source: Toxicology Mechanisms and Methods, Volume 19, Number 8, October 2009 , pp. 510-517(8)

Publisher: Informa Healthcare

In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation

Authors: Chetty, Manoranjenni; d'Esposito, Fabrizio; Zhang, Wei V.; Glen, John; Dore, Glenys; Stankovic, Zvijezdana; Edwards, Robert J.; Ramzan, Iqbal; Murray, Michael

Source: British Journal of Clinical Pharmacology, Volume 68, Number 4, October 2009 , pp. 574-579(6)

Publisher: Blackwell Publishing

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4′-methanol-bisbenzonitrile in vitro

Authors: Jeong, Seongwook; Woo, Margaret; Flockhart, David; Desta, Zeruesenay

Source: Cancer Chemotherapy and Pharmacology, Volume 64, Number 5, October 2009 , pp. 867-875(9)

Publisher: Springer

Muscarinic receptor activation in the lumbosacral spinal cord ameliorates bladder irritation in rat cystitis models

Authors: Masuda, Hitoshi; Ichiyanagi, Nobutaka; Yokoyama, Minato; Sakai, Yasuyuki; Kihara, Kazunori; Chancellor, Michel B.; de Groat, William C.; Yoshimura, Naoki

Source: BJU International, Volume 104, Number 10, November 2009 , pp. 1531-1537(7)

Publisher: Blackwell Publishing

Polymorphism of Human Cytochrome P450 2D6 and Its Clinical Significance: Part I

Author: Zhou, Shu-Feng

Source: Clinical Pharmacokinetics, Volume 48, Number 11, 1 November 2009 , pp. 689-723(35)

Publisher: Adis International

Immunotherapy in Elderly Transplant Recipients: A Guide to Clinically Significant Drug Interactions

Author: Kuypers, Dirk R.J.

Source: Drugs & Aging, Volume 26, Number 9, 1 September 2009 , pp. 715-737(23)

Publisher: Adis International

Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor α agonist in preclinical species and human

Authors: Frederick, K.S.; Maurer, T.S.; Kalgutkar, A.S.; Royer, L.J.; Francone, O.L.; Winter, S.M.; Terra, S.G.; Chen, D.; Gao, X.

Source: Xenobiotica, Volume 39, Number 10, October 2009 , pp. 766-781(16)

Publisher: Informa Healthcare

Heat Shock Protein 90 - a Potential Target in the Treatment of Human Acute Myelogenous Leukemia

Authors: Reikvam, H.; Ersvær, E.; Bruserud, O.

Source: Current Cancer Drug Targets, Volume 9, Number 6, September 2009 , pp. 761-776(16)

Publisher: Bentham Science Publishers

A Proposal for a Pharmacokinetic Interaction Significance Classification System (PISCS) Based on Predicted Drug Exposure Changes and Its Potential Application to Alert Classifications in Product Labelling

Authors: Hisaka, Akihiro; Kusama, Makiko; Ohno, Yoshiyuki; Sugiyama, Yuichi; Suzuki, Hiroshi

Source: Clinical Pharmacokinetics, Volume 48, Number 10, 1 October 2009 , pp. 653-666(14)

Publisher: Adis International

Letrozole: A Review of its Use in the Treatment of Postmenopausal Women with Hormone-Responsive Early Breast Cancer

Author: Keating, Gillian M.

Source: Drugs, Volume 69, Number 12, 20 August 2009 , pp. 1681-1705(25)

Publisher: Adis International

Importance of Influx and Efflux Systems and Xenobiotic Metabolizing Enzymes in Intratumoral Disposition of Anticancer Agents

Author: Rochat, B.

Source: Current Cancer Drug Targets, Volume 9, Number 5, August 2009 , pp. 652-674(23)

Publisher: Bentham Science Publishers

Fragment-based prediction of cytochromes P450 2D6 and 1A2 inhibition by recursive partitioning

Authors: Burton, J.; Danloy, E.; Vercauteren, D. P.

Source: SAR and QSAR in Environmental Research, Volume 20, Numbers 3-4, April 2009 , pp. 185-205(21)

Publisher: Taylor and Francis Ltd

Substrate Specificity, Inhibitors and Regulation of Human Cytochrome P450 2D6 and Implications in Drug Development

Authors: Zhou, Shu-Feng; Liu, Jun-Ping; Lai, Xin-Sheng

Source: Current Medicinal Chemistry, Volume 16, Number 21, July 2009 , pp. 2661-2805(145)

Publisher: Bentham Science Publishers

Synthesis, Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives

Authors: Kus, Canan; Ayhan-K1lc1gil, Gulgun; Tuncbilek, Meral; Altanlar, Nurten; Coban, Tulay; Can-Eke, Benay; Iscan, Mumtaz

Source: Letters in Drug Design & Discovery, Volume 6, Number 5, July 2009 , pp. 374-379(6)

Publisher: Bentham Science Publishers

Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development

Authors: Mori, K.; Hashimoto, H.; Takatsu, H.; Tsuda-Tsukimoto, M.; Kume, T.

Source: Xenobiotica, Volume 39, Number 6, June 2009 , pp. 415-422(8)

Publisher: Informa Healthcare

An inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats

Authors: Mei, Li; Zhang, Lixin; Dai, Renke

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Number 3, June 2009 , pp. 753-762(10)

Publisher: Informa Healthcare

Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages

Authors: Lacour, Sandrine; Antonios, Diane; Gautier, Jean-Charles; Pallardy, Marc

Source: Journal of Immunotoxicology, Volume 6, Number 2, June 2009 , pp. 84-93(10)

Publisher: Informa Healthcare

Effect of rifampin on the pharmacokinetics and pharmacodynamics of prasugrel in healthy male subjects

Authors: Farid, N. A.; Jakubowski, J. A.; Payne, C. D.; Li, Y. G.; Jin, Y.; Ernest, C. S.; Winters, K. J.; Brandt, J. T.; Salazar, D. E.; Small, D. S.

Source: Current Medical Research and Opinion, Volume 25, Number 8, August 2009 , pp. 1821-1829(9)

Publisher: Informa Healthcare