Computational Insights into Binding of Bisphosphates to Farnesyl Pyrophosphate Synthase
Keywords: Bisphosphonate; Bisphosphonates (BPs); Charge transfer plus higher-order mixed terms; Farnesyl Pyrophosphate Synthase; Geranyl Pyrophosphate; Isopentenyl Pyrophosphate; Isothermal titration calorimetry; Minodronic acid; Nitrogen-containing BPs; Paget's disease; Protein Data Bank; adenosine triphosphate; alendronate; antiresoptive activity; bone resorption; dispersion; drug design; electrostatic; enthalpy-driven; farnesyl pyrophosphate synthase; fragment molecular; ibandronate; ibandronate model; imidazopyrizine; isopentenyl pyrophosphate; isoprenyl synthases; isothermal titration calorimetry; mevalonate pathway; minodronate; osteoclast; osteoporosis; pamidronate; protein-ligand binding; quantum mechanics; risedronate; tiludronate; zoledronate
Document Type: Research Article
Publication date: 01 January 2011
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