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Free Content Asymmetric syntheses of both enantiomers of amphetamine hydrochloride via bakers‘ yeast reduction of phenylacetone

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Both enantiomers of amphetamine hydrochloride were stereospecifically synthesised based on bakers‘ yeast reduction of phenylacetone. A simple and efficient method for the chiral inversion of (S)-1-phenyl-2-propanol 3 to (R)-1-phenyl-2-propanol 8 has been discussed.
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Keywords: ASYMMETRIC SYNTHESIS, AMPHETAMINES, BAKERS‘ YEAST, CHIRAL INVERSION

Document Type: Research Article

Publication date: 01 October 2004

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  • The Journal of Chemical Research is a monthly journal which has a broad international authorship and publishes research papers and reviews in all branches of experimental chemistry.

    Established in 1977 as a joint venture by the British, French and German chemical societies it maintains the high standards set by the founding societies. Each paper is independently peer reviewed and only carefully evaluated contributions are accepted.

    Recent papers have described new synthetic methods, new heterocyclic compounds, new natural products, and the inorganic chemistry of metal complexes.

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