Neonatal Alloimmune Thrombocytopenia: A Case Study

NEONATAL ALLOIMMUNE thrombocytopenia (NAIT) is a life-threatening disorder caused by fetomaternal platelet incompatibility analogous to that seen in rhesus (Rh) disease. In NAIT , maternal immunoglobulin G (IgG) antiplatelet antibodies cross the placenta, resulting in rapid destruction and removal of fetal platelets by the reticuloendothelial system. Studies have shown that NAIT has an incidence of 1 of 1,000 live births, with a mortality rate of 10–15 percent and the risk of long–term morbidities up to 20–60 percent if intracranial hemorrhage (ICH) occurs.