Comparative utility of interferon-γ release assay, QuantiFERON® TB-GIT and T-SPOT®.TB in rheumatoid arthritis
OBJECTIVE: To compare two interferon-γ release assays (IGRAs), QuantiFERON®-TB Gold In-Tube (QFT) and T-SPOT®.TB (T-SPOT), in RA patients for detecting latent tuberculous infection (LTBI).
DESIGN: QFT and T-SPOT were conducted concurrently in 230 prospectively enrolled RA patients.
RESULTS: There were no active TB patients. The percentage of QFT- and T-SPOT-positive patients was respectively 8.3% and 5.7%. In patients aged 60 years, these proportions were respectively 12.3% and 7.2%. The percentage of QFT positivity and T-SPOT positivity at age <60 years was respectively 2.2% and 3.3%. After multivariate logistic analysis for QFT positivity, age 60 years and TB suspected based on chest X-ray were selected as independent factors, with adjusted odds ratios of respectively 4.73 and 3.25. No factors were selected for T-SPOT positivity.
CONCLUSION: QFT had a higher positivity rate. In the light of the previous estimated rate of LTBI in Japan, both IGRAs underestimate LTBI, and neither IGRA has enough capability to detect LTBI.
Document Type: Research Article
Affiliations: 1: Center of Rheumatology, Allergy & Clinical Immunology, National Hospital Organization Chiba-East Hospital, Chiba, Japan 2: Department of Respiratory Medicine, National Hospital Organization Chiba-East Hospital, Chiba, Division of Infection Control, Chiba University Hospital, Chiba, Japan 3: Department of Respiratory Medicine, National Hospital Organization Chiba-East Hospital, Chiba, Japan 4: Chiba Foundation for Health Promotion and Disease Prevention, Chiba, Japan
Publication date: 2016-11-01
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