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Free Content Development of tuberculosis in immunocompromised patients with a positive tuberculosis-specific IGRA [Short communication]

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There is a lack of data on the predictive value of tuberculosis (TB) specific interferon-gamma release assays (TIGRAs) for both immunocompetent and immunocompromised individuals. We retrospectively followed up 460 such patients after QuantiFERON®-TB Gold In-Tube (QFT-GIT) testing (mean follow-up 28 months) by reviewing patient charts. A total of 1/38 QFT-GIT-positive and no QFT-GIT-negative patients developed active TB. The incidence rate of progression to active TB assessed retrospectively in these patients after positive TIGRA was therefore low (1.2 events/100 person-years). The need for careful follow-up and prophylactic therapy after positive TIGRA in this patient group needs to be evaluated prospectively.
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Keywords: interferon-gamma release assay; risk of progression; tuberculosis

Document Type: Research Article

Affiliations: 1: Center for Infectious Diseases and Travel Medicine, Freiburg, Germany; IFB–Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany 2: Center for Infectious Diseases and Travel Medicine, University Hospital Freiburg, Freiburg, Germany 3: Center for Infectious Diseases and Travel Medicine, and IFB–Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany

Publication date: 01 April 2012

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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