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Free Content Treatment outcome of multidrug-resistant tuberculosis among Vietnamese immigrants

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OBJECTIVE: To review the outcome for MDR-TB treatment among potential migrants from Vietnam.

SETTING: All cases of documented MDR-TB treated by the International Organization of Migration (IOM) in Vietnam from 1989 to 2000 were reviewed.

METHODS: MDR-TB was defined as isoniazid- and rifampicin-resistant Mycobacterium tuberculosis. All cases of TB treated by the IOM and recorded in the computerised database were reviewed to identify MDR-TB cases. Demographics, chest radiograph results, drug resistance, drug use and dosage, duration of treatment, and outcome were analysed.

RESULTS: Forty-four cases of MDR-TB were identified. Treatment consisted of ambulatory directly observed treatment with an 8-drug protocol: isoniazid, rifampicin, pyrazinamide, ethambutol, capreomycin, ethionamide, ofloxacin and cycloserine. This initial protocol was modified due to drug availability or drug intolerance. Patients were treated with a median of 8 drugs (range 6–12). Mean duration of treatment for MDR-TB was 23.0 (SD ± 11.4) months. Thirty-eight (86%) patients were cured and emigrated, one failed treatment (2%), three were lost to follow-up (7%) and two died (4%).

CONCLUSION: Treatment for MDR-TB provided by the IOM was effective in preparing a low-income population for migration.
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Keywords: migration; multidrug resistant tuberculosis; treatment outcome

Document Type: Regular Paper

Affiliations: 1: Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada 2: International Organization for Migration, Ho Chi Minh City, Vietnam

Publication date: 01 February 2005

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  • The International Journal of Tuberculosis and Lung Disease publishes articles on all aspects of lung health, including public health-related issues such as training programmes, cost-benefit analysis, legislation, epidemiology, intervention studies and health systems research. The IJTLD is dedicated to the continuing education of physicians and health personnel and the dissemination of information on tuberculosis and lung health world-wide.

    Certain IJTLD articles are selected for translation into French, Spanish, Chinese or Russian. They are available on the Union website

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