Treatment outcome of multidrug-resistant tuberculosis among Vietnamese immigrants
SETTING: All cases of documented MDR-TB treated by the International Organization of Migration (IOM) in Vietnam from 1989 to 2000 were reviewed.
METHODS: MDR-TB was defined as isoniazid- and rifampicin-resistant Mycobacterium tuberculosis. All cases of TB treated by the IOM and recorded in the computerised database were reviewed to identify MDR-TB cases. Demographics, chest radiograph results, drug resistance, drug use and dosage, duration of treatment, and outcome were analysed.
RESULTS: Forty-four cases of MDR-TB were identified. Treatment consisted of ambulatory directly observed treatment with an 8-drug protocol: isoniazid, rifampicin, pyrazinamide, ethambutol, capreomycin, ethionamide, ofloxacin and cycloserine. This initial protocol was modified due to drug availability or drug intolerance. Patients were treated with a median of 8 drugs (range 6–12). Mean duration of treatment for MDR-TB was 23.0 (SD ± 11.4) months. Thirty-eight (86%) patients were cured and emigrated, one failed treatment (2%), three were lost to follow-up (7%) and two died (4%).
CONCLUSION: Treatment for MDR-TB provided by the IOM was effective in preparing a low-income population for migration.
Document Type: Regular Paper
Affiliations: 1: Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada 2: International Organization for Migration, Ho Chi Minh City, Vietnam
Publication date: 01 February 2005
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