Effect of surfactants on the solubility and intrinsic dissolution rate of sparfloxacin
The effect of surfactants on the solubility and intrinsic dissolution rate of sparfloxacin was investigated at room temperature. The surfactants used in the study were anionic sodium lauryl sulfate (SLS) and nonionic polysorbate 80 (Tween 80). Sodium lauryl sulfate showed very significant increase in solubility Tween 80 at the highest concentration studied. The intrinsic dissolution rates were determined compared to at the same surfactant concentrations used in the solubility study by rotating disk method. Diffusion coefficient (D) of sparfloxacin was evaluated to be 7.19 × 10 –6cm 2s –1and the apparent mean diffusion coefficient for sparfloxacin-loaded micelle was estimated to 3.98 × 10 –6and 2.21 × 10 –6cm2s –1in Tween 80 and SLS respectively.
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Document Type: Research Article
Publication date: 01 March 2011
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