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Open Access Biopharmaceutical characterization of some new papaverine decomposition products

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2,3,9,10-Tetramethoxy-12-oxo-12- H -indolo [2,1- a]isoquinolinium chloride 1 (compound X) and 13-(3,4dimethoxyphenyl)-2,3,8,9-tetramethoxy-6 a ,12 a -diazadibenzo [a, g] fluorenylium chloride 2 (compound NF) are new papaverine oxidation products. A solution of compound 1 bleaches on addition of sodium hydroxide solution. A new entity, 2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt 3 (compound WP), is formed. The physico-chemical properties of compounds 1–3, such as solubility in water and lipophilicity, have been measured. The IC50 for compounds 1 and 3 was also assessed.
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Document Type: Research Article

Publication date: 01 March 2011

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  • Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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