Alginate-chitosan film for ocular drug delivery: Effect of surface cross-linking on film properties and characterization
The characteristics of alginate-chitosan films intended for ocular drug delivery of gatifloxacin sesquihydrate were compared with the ionically surface cross-linked films of similar compositions. The effect of polymer ratios and cross-linking was studied relatively to various parameters
of formulations including physicochemical, mechanical strength, swelling and bioadhesion. The drug release profiles and drug release mechanisms were compared. The folding endurance, tensile strength, bioadhesive strength considerably increased whereas swelling index, elongation at break decreased
with surface cross-linking of the films. Surface cross-linked formulation F3 (2% w/v sodium alginate and 1% w/v chitosan) showed most prolonged drug release of 24 h indicating the potential of surface cross linking of the film to sustain drug release. As per the kinetic models
both type of films showed a constant drug release, however the drug release mechanism transformed from erosion to diffusion after cross linking. These results demonstrate that the surface treated alginate-chitosan film could be a potential vehicle to enhance ocular GS bioavailability and patient
compliance.
Document Type: Research Article
Affiliations: 1: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Haryana, India 2: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Haryana, 125 001, India, Email: [email protected]
Publication date: 01 August 2008
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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