Deviations of drug solubility in water-cosolvent mixtures from the Jouyban-Acree model – effect of solute structure
Deviations of the predicted solubilities using the Jouyban-Acree model from experimental data were correlated to the structural descritptors of the drugs computed by HyperChem® software. The proposed models are able to predict the solubility in water-cosolvent mixtures and reduced
the mean percentage deviations (MPD) of predicted solubilities from 24%, 48%, and 53% to 16%, 33% and 38%, respectively for water-propylene glycol, water-ethanol and water-polyethylene glycol 400 mixtures, with the overall improvement in prediction
capability of the model being ∼13%.
Document Type: Research Article
Affiliations: 1: Faculty of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 51664, Iran, Email: [email protected] 2: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 3: Medway School of Pharmacy, University of Kent and Greenwich, Chatham, United Kingdom 4: Pharmaceutical Nanotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 5: Department of Chemistry, University of North Texas, Denton, USA
Publication date: 01 February 2008
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
- Information for Authors
- Submit a Paper
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content