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Home / Die Pharmazie - An International Journal of Pharmaceutical Sciences, Volume 60, Number 4

Open Access Cytotoxic and antioxidant activity of Achillea alexandri-regis

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The cytotoxicity and antioxidant properties of herb extracts of Achillea alexandri-regis were studied. Combined chloroform and ethylacetate extracts exhibited a pronounced cytotoxic effect against HeLa cancer cells (IC50 = 25.92 ± 4.96 μg/ml), and lower cytotoxicity against K562 leukemia cells (IC50 = 48.59 ± 18.31 μg/ml). The methanol extract was found to be a moderately cytotoxic in vitro agent against HeLa and K562 cells. No suppressive activity was detected on non-malignant peripheral blood mononuclear cells (PBMC). The antioxidant activity of the methanol extract was assessed by DPPH radical scavenging. The methanol extract of A. alexandri-regis showed concentration dependent DPPH radical scavenging activity with IC50 = 36.14 ± 0.05 μg/ml.

Document Type: Short Communication

Affiliations: 1: Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade, 11000, Serbia and Montenegro, Email: [email protected] 2: Institute for Oncology and Radiology of Serbia, Belgrade, Serbia and Montenegro 3: Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia and Montenegro

Publication date: 01 April 2005

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