Alkaline hydrolysis of cladribine
The kinetics of hydrolysis of 2-chloro-2′-deoxyadenosine (cladribine) was studied at various sodium hydroxide concentrations and temperatures. HPLC analysis of reaction mixtures showed that the main products were 2′-deoxyisoguanosine and 2′-deoxyguanosine. The first
one was the result of the hydroxyl anion attack, whereas the presence of the other nucleoside has evidenced the existence of hitherto undescribed rearrangement reaction in purine derivatives.
Document Type: Research Article
Affiliations: 1: Institute of Chemistry, Agricultural University, Warsaw, Poland 2: Department of Drug Chemistry, Medical University of Warsaw, Warsaw, Poland 3: Institute of Chemistry, Agricultural University, 159C Nowoursynowska st., Warsaw, PL-02-787, Poland, Email: [email protected] 4: Laboratory of Experimental Pharmacology, Polish Academy of Sciences, Medical Research Center, Warsaw, Poland
Publication date: 01 February 2003
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