Acoustical Studies of Narcotic-Analgesic Drugs in Aqueous-Alcoholic Mixtures at 25 °C
Density and ultrasonic velocity of drugs Tramacip and Parvodex have been measured in various aqueous-alcoholic (MeOH, EtOH and 1-PrOH) mixtures at 25 °C. The experimental data have been used to estimate various acoustic parameters, such as specific acoustic impedance (Z),
relative association (R.A.), adiabatic compressibility (β), intermolecular free length (Lf
), molar volume (Vm
), molar sound velocity (Rm
) and Wada's constant (W). Variation of these parameters in various alcoholic systems
has been discussed in terms of the length of the alcohol, the molecular volume, as well as inter/intramolecular interactions of these aqueous – alcoholic systems. The results of these studies would be helpful for pharmacological use of these drugs.
Document Type: Research Article
Publication date: 01 July 2007
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