Calcium-Independent Membrane Damage by Venom Phospholipases A2
Many snake venom phospholipase A2s (vPLA2s) present biological effects that are independent of hydrolytic activity. Here we review the evidence for the calcium-independent membrane damaging activity of vPLA2s, the possible relevance of this activity on their biological effects, and models for the mechanism of membrane permeabilization by these proteins.
Keywords: Membrane permeabilization; micelle nucleation; molecular mechanism
Document Type: Research Article
Publication date: 01 August 2009
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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