Skip to main content

Investigation on Polymorphic Behavior of Progesterone and Stabilization by Co-Crystallization: A Review

Buy Article:

$55.00 plus tax (Refund Policy)

Progesterone, extensively used in human as well as veterinary medicines is a progestogen type of hormone. With the aim for hunting the stable polymorph, this review examines polymorphic behavior of progesterone and stabilization of less stable form by co-crystallization. An overview of two monotropically related forms of progesterone – form-I and form-II, synthetic enantiomer, ent-progesterone and racemic progesterone is provided. Different methods reported in the literature for the formation of polymorphs of progesterone are discussed here. After extensive manual screening it has been found that, though there are few methods mentioned in the literature for the formation of form-II, there is a lack of reproducibility in the recipes. This contribution also briefly reviews three other forms of progesterone (form-III, form-IV and form-V) which appear only in equilibrium melt and cannot be structurally characterized. Finally, comparison of different physical properties of form-I and form-II are also addressed.
No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: Form-I; Form-II; Polymorphic behavior; Progesterone; Review

Document Type: Research Article

Publication date: 2014-08-01

More about this publication?
  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more