Skip to main content

Antimicrobial Activity and SAR Study of Some Novel Thiosemicarbazide Derivatives Bearing Piperidine Moiety

Buy Article:

$63.00 + tax (Refund Policy)

In this study novel thiosemicarbazides bearing piperidine moiety were synthesized in order to investigate their possible antibacterial and antifungal activities. A structure-activity relationship (SAR) study including conformational analysis and some physicochemical descriptors was carried out to provide the guidance for further synthetic work. The significant molecular descriptors related to the compounds with antifungal activity were: electrostatic potential surface, the highest occupied molecular orbital energy, surface area, volume, and hydration energy.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Antibacterial activity; antibiotics point; antifungal activity; bacterial pathogens; cationic polypeptides; conformational analysis; electrostatic potential surface; physicochemical descriptors; piperidine derivatives; thiosemicarbazide derivatives

Document Type: Research Article

Publication date: 01 November 2011

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more