Chiral Phosphoric Acid Catalyzed Diastereo- and Enantioselective 1,4- Conjugate Addition of β-Ketoesters to Nitroolefins
Chiral phosphoric acid as organocatalyst for the diastereo- and enantioselectivity 1,4-conjugate addition of a variety of β-ketoesters to nitroolefins was firstly developed, providing the corresponding adducts in high yield (up to 97%) with moderate diastereoselectivities (up to 2.6:1 dr) and enantioselectivities (up to 58% ee).
Keywords: 1,4-conjugate addition; Chiral phosphoric acid; asymmetric catalysis; nitroolefins; organocatalysis; β-ketoesters
Document Type: Research Article
Publication date: 01 April 2010
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